Category Health/Medical

Finding sheds light on why mutations of the gene p53 are associated with cancer and could lead to new diagnostics or treatments
About half of all tumors have mutations of the gene p53, normally responsible for warding off cancer. Now, UT Southwestern scientists have discovered a new role for p53 in its fight against tumors: preventing retrotransposons, or “jumping genes,” from hopping around the human genome. In cells with missing or mutated p53, the team found, retrotransposons move and multiply more than usual...

A new study published in the journal Psychological Science found that people who feel enthusiastic and cheerful — what psychologists call “positive affect” — are less likely to experience memory decline as they age. This result adds to a growing body of research on positive affect’s role in healthy aging.

A team of researchers analyzed data from 991 middle-aged and older U.S...

According to the American Heart Association, heart disease is the leading cause of death worldwide in recent years. During a heart attack, or myocardial infarction (MI), a blocked artery and the resulting oxygen deprivation cause massive cardiac cell death, blood vessel impairment and inflammation. Now, researchers reporting in ACS Biomaterials Science & Engineering have developed a cardiac patch with tiny engineered blood vessels that improved recovery from MI in rats and pigs.

To effectively treat MI, lost heart muscle tissue must regenerate and new blood vessels must form to restore oxygen and nutrients to cells...

With insights into a molecular pathway that regulates the activity of Tregs, a type of T cell involved in immunosuppression, new research opens up possibly new avenues for treating inflammatory and autoimmune diseases.

Immune response is a balancing act: Too much can lead to inflammatory or autoimmune disease; too little could lead to a serious infection...