Category Health/Medical

Blood Vessel cells implicated in Chronic Inflammation of Obesity

A UTSW study identified a type of blood vessel cell that triggers inflammation in fat tissue. Above, inflammatory immune cells (green) surround fat cells (red) in obesity and contribute to the development of metabolic disease.

When fat cells in the body are stuffed with excess fat, the surrounding tissue becomes inflamed. That chronic, low-level inflammation is one of the driving factors behind many of the diseases associated with obesity. Now, UT Southwestern scientists have discovered a type of cell responsible, at least in mice, for triggering this inflammation in fat tissue. Their findings, published in Nature Metabolism, could eventually lead to new ways to treat obesity.

“The inflammation of fat cells in obese individuals is linked to many of the comorbidities we associate wit...

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LSU Health New Orleans Discovers Potential New Rx Strategy for Stroke

Αmyloid β peptide–mediated damage

Research conducted at LSU Health New Orleans Neuroscience Center of Excellence reports that a combination of LSU Health-patented drug and selected DHA derivatives is more effective in protecting brain cells and increasing recovery after stroke than a single drug. The findings are published in Brain Circulation, available here.

Nicolas Bazan, MD, PhD, Boyd Professor, Professor of Neurology and Director of the Neuroscience Center of Excellence at LSU Health New Orleans School of Medicine, and Ludmila Belayev, MD, LSU Health New Orleans Professor of Neuroscience, Neurology, and Neurosurgery, discovered this novel therapeutic strategy for ischemic stroke using an experimental model

During an ischemic stroke, signals are produced from arriving blood white cells and primary brain immu...

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Brain Imaging predicts PTSD after brain injury

This shows the outline of a brain in a woman's head
Together, the findings suggest that a “brain reserve,” or higher cortical volumes, may provide some resilience against PTSD. Image is in the public domain

Brain volume measurement may provide early biomarker. Posttraumatic stress disorder (PTSD) is a complex psychiatric disorder brought on by physical and/or psychological trauma. How its symptoms, including anxiety, depression and cognitive disturbances arise remains incompletely understood and unpredictable. Treatments and outcomes could potentially be improved if doctors could better predict who would develop PTSD. Now, researchers using magnetic resonance imaging (MRI) have found potential brain biomarkers of PTSD in people with traumatic brain injury (TBI).

The study appears in Biological Psychiatry: Cognitive Neuroscience a...

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Astrocytes eat Connections to maintain Plasticity in Adult Brains

Image: A 3-D animated image showing our synapse phagocytosis reporter in mouse hippocampus. Presynapses in green, astrocytes in white, and microglia in blue. Phagocytosed presynapses by glia were shown in red.
 Image: A 3-D animated image showing our synapse phagocytosis reporter in mouse hippocampus. Presynapses in green, astrocytes in white, and microglia in blue. Phagocytosed presynapses by glia were shown in red.

Developing brains constantly sprout new synapses as they learn and remember. Important connections — the ones that are repeatedly introduced, such as how to avoid danger — are nurtured and reinforced, while connections deemed unnecessary are pruned away. Adult brains undergo similar pruning, but it was unclear how or why synapses in the adult brain get eliminated.

Now, a team of researchers based in Korea has found the mechanism underlying plasticity and, potentially, neurological disorders in adult brains. They published their findings on December 23 in Nature.

“Our findi...

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