Category Health/Medical

Something old, something New Combine for Effective Vaccine against Parasitic Skin Disease

3D illustration of one phase of the life cycle of the parasite that causes cutaneous leishmaniasis
Illustration: Shutterstock.com

Scientists use CRISPR to edit structural gene in organism that causes leishmaniasis. Scientists are planning for Phase 1 human trials of a vaccine they developed by using CRISPR gene-editing technology to mutate the parasite that causes leishmaniasis, a skin disease common in tropical regions of the world and gaining ground in the United States.

“If you assure protection in the sand fly model, then you have a good shot at a real vaccine,” said Abhay Satoskar, a co-lead investigator of the work and professor of pathology and microbiology at The Ohio State University.

The team applied the new technology to the century-old Middle Eastern practice of le...

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Discovery Enables Adult Skin to Regenerate like a Newborn’s

An image of a regenerating skin wound with hair follicles that can make goose bumps. The green lines are the muscles attached to individual regenerating hairs so that they can stand up.

A newly identified genetic factor allows adult skin to repair itself like the skin of a newborn babe. The discovery by Washington State University researchers has implications for better skin wound treatment as well as preventing some of the aging process in skin.

In a study, published in the journal eLife on Sept. 29, the researchers identified a factor that acts like a molecular switch in the skin of baby mice that controls the formation of hair follicles as they develop during the first week of life. The switch is mostly turned off after skin forms and remains off in adult tissue...

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Strong Activation of Anti-bacterial T cells linked to Severe COVID-19

Illustration of T cells fighting virus
Illustration: Getty Im“MAIT cell activation and dynamics associated with COVID-19 disease severity,” Parrot, T., Gorin, J. B., Ponzetta, A., Maleki, K. T., Kammann, T., Emgård, J., Perez-Potti, A., Sekine, T., Rivera-Ballesteros, O., the Karolinska COVID-19 Study Group, Gredmark-Russ, S., Rooyackers, O., Folkesson, E., Eriksson, L. I., Norrby-Teglund, A., Ljunggren, H. G., Björkström, N. K., Aleman, S., Buggert, M., Klingström, J., Strålin, K., and Sandberg, J. K., Science Immunology, online 28 september, 2020, doi: 10.1126/sciimmunol.abe1670ages

A type of anti-bacterial T cells, so-called MAIT cells, are strongly activated in people with moderate to severe COVID-19 disease, according to a study by researchers at Karolinska Institutet in Sweden that is published in the journal...

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First Evidence that Air Pollution Particles and Metals are Reaching the Placenta

Black inclusions in placental cells resembling inhaled particulate matter

Pollution particles, including metals, have been found in the placentas of fifteen women in London, according to research led by Queen Mary University of London.

The study, funded by Barts Charity and published in the journal Science of The Total Environment, demonstrate that inhaled particulate matter from air pollution can move from the lungs to distant organs, and that it is taken up by certain cells in the human placenta, and potentially the fetus.

The researchers say that further research is needed to fully define the direct effect that pollution particles may have on the developing fetus.

Lead author Professor Jonathan Grigg from Queen Mary University of London said: “Our study for the first time shows that ...

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