Category Health/Medical

NextGen Organoids Grow and Function like Real Tissues

Next-gen organoids grow and function like real tissues
Fluorescence image of a mini-gut with characteristic crypts containing labeled stem cells (red). Credit: M. Nikolaev, Lutolf Lab (EPFL)

Bioengineers have created miniature intestines in a dish that match up anatomically and functionally to the real thing better than any other lab-grown tissue models. The biological complexity and longevity of the new organoid technology is an important step towards enabling drug testing, personalized medicine, and perhaps, one day, transplantations.

Organoids are fast-becoming one of the most cutting-edge tools of modern life sciences. The idea is to use stem cells to build miniature tissues and organs that accurately resemble and behave like their real counterparts.

One can immediately appreciate the value of organoids for both research and medi...

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Insomnia Identified as a new Risk Factor for type 2 Diabetes in new study which also confirms many other Risk and Protective Factors

A new ‘global atlas’ study published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) is the first to identify insomnia as a risk factor associated with increased risk of developing type 2 diabetes (T2D). The study identifies 34 risk factors that are thought to increase (19) or decrease risk (15), as well as a further 21 ‘suggestive’ risk factors where evidence was not quite as strong.

The study by Associate Professor Susanna Larsson and by Shuai Yuan of the Karolinska Institutet, Stockholm, Sweden, used a technique called ‘Mendelian Randomisation’ (MR), which uses genetic variation as a natural experiment to investigate the causal relations between potentially modifiable risk factors and health outcomes in observational data...

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Linking Calorie Restriction, Body Temperature and Healthspan

Metabolic adaptation to calorie restrictionScience Signaling, 2020; 13 (648): eabb2490 DOI: 10.1126/scisignal.abb2490

Cutting calories significantly may not be an easy task for most, but it’s tied to a host of health benefits ranging from longer lifespan to a much lower chance of developing cancer, heart disease, diabetes and neurodegenerative conditions such as Alzheimer’s.

A new study from teams led by Scripps Research Professors Bruno Conti, PhD, and Gary Siuzdak, PhD, illuminates the critical role that body temperature plays in realizing these diet-induced health benefits. Through their findings, the scientists pave the way toward creating a medicinal compound that imitates the valuable effects of reduced body temperature.

The research appears in Science Signaling.

Conti has spent...

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A new Twist on DNA Origami

Models and transmission electron microscopy images of various 3D polyhedra that were constructed by connecting the self-linked triangular M-DNA and rectangular M-DNA. From left to right: a tetrahedron, triangular bipyramid, octahedron, pentagonal bipyramid, triangular prism, rectangular prism, pentagonal prism and hexagonal prism

Meta-DNA structures transform the DNA nanotechnology world...

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