Category Health/Medical

Elderly People protected against Respiratory Infections by BCG Vaccine

ACTIVATE: Randomized Clinical Trial of BCG Vaccination Against Infection in the ElderlyCell, Aug. 31, 2020; DOI: 10.1016/j.cell.2020.08.051

However, the effect of the vaccine specifically against COVID-19 has not been demonstrated. The BCG vaccine, an old treatment originally developed for tuberculosis, has a broad, stimulating effect on the immune system. This gives it an effective preventive action against various infections — possibly also against COVID-19. It is frequently given to children, but in this double-blind randomized clinical study, a collaboration between Radboud University Medical Center and the National and Kapodistrian University of Athens it was shown that elderly people also benefit from it. The results of the study are in Cell.

At Radboudumc, Professor of Expe...

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Unique Antibody Profile sets Gluten Sensitivity apart from Celiac disease

Subclass Profile of IgG Antibody Response to Gluten Differentiates Non-Celiac Gluten Sensitivity from Celiac Disease

Subclass Profile of IgG Antibody Response to Gluten Differentiates Non-Celiac Gluten Sensitivity from Celiac Disease

A new study of the antibodies produced by people with gluten sensitivity may lead to a better way to detect the condition and treat it.
Until recently, many doctors often dismissed the complaints of people who claimed to be sensitive to foods containing gluten but did not have celiac disease, a well-documented autoimmune disease triggered by exposure to the dietary protein found in wheat, rye, and barley.

That view has changed in the past few years, based partly on studies by Armin Alaedini, PhD, assistant professor of medicine at Columbia University Vagelos College of Physicians and Surgeons, that have delved into the biological basis for non-celiac gluten sensitivity.

But ...

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Synthetic Compound could serve as Prototype for Novel Class of Drugs to Treat Neurological Damage

CPTX (orange) combines functional domains present in synaptic organizing proteins in a unique way. The compound was designed to act as a universal buridge builder for excitatory connections between nerve cells. Source: DZNE/Alexander Dityatev

Researchers from the German Center for Neurodegenerative Diseases (DZNE), UK and Japan have developed a neurologically acting protein and tested it in laboratory studies. In mice, the experimental compound ameliorated symptoms of certain neurological injuries and diseases, while on the microscopic level it was able to establish and repair connections between neurons. This proof-of-principle study suggests that biologics, which act on neuronal connectivity, could be of clinical use in the long term. The results are published in the journal Science.

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Researchers 3D Print lifelike Heart Valve Models

Model
Patient-specific organ models, which include integrated 3D-printed soft sensor arrays, are fabricated using specialized inks and a customized 3D printing process. Such models can be used in preparation for minimally invasive procedures to improve outcomes in thousands of patients worldwide. Credit: McAlpine Group, University of Minnesota

Organ model could improve surgical outcomes for thousands of patients worldwide. Researchers from the University of Minnesota, with support from Medtronic, have developed a groundbreaking process for multi-material 3D printing of lifelike models of the heart’s aortic valve and the surrounding structures that mimic the exact look and feel of a real patient.

These patient-specific organ models, which include 3D-printed soft sensor arrays integrated in...

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