Category Health/Medical

Researchers discover the Microbiome’s role in attacking Cancerous Tumors

The Microbiome's Role in Attacking Cancerous Tumors | Technology ...
Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapyScience, 2020; eabc3421 DOI

Researchers with the Snyder Institute for Chronic Diseases at the Cumming School of Medicine (CSM) have discovered which gut bacteria help our immune system battle cancerous tumours and how they do it. The discovery may provide a new understanding of why immunotherapy, a treatment for cancer that helps amplify the body’s immune response, works in some cases, but not others. The findings, published in Science, show combining immunotherapy with specific microbial therapy boosts the ability of the immune system to recognize and attack cancer cells in some melanoma, bladder and colorectal cancers.

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New Insights into Lung Tissue in COVID-19 disease

Sections through the three-dimensional reconstruction volume (upper left, grey) around a pulmonary alveolus with hyaline membrane (lower left, yellow). On the right, the images are superimposed. In the centre is the air bubble (alveolus). The electron density is represented by different shades of grey. On the inside of the air bubble is a layer of proteins and dead cell residues, the “hyaline membrane”. This deposit, which can be represented in its three-dimensional structure for the first time by the new method, reduces the gas exchange and leads to respiratory distress.

Photo: Tim Salditt, Marina Eckerman

Physicists at the University of Göttingen, together with pathologists and lung specialists at the Medical University of Hannover, have developed a 3D imaging technique that enables h...

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Mild COVID-19 cases can produce strong T cell Response

SARS-CoV-2 , COVID-19
Colorized scanning electron micrograph of a cell (blue) heavily infected with SARS-CoV-2 virus particles (red), isolated from a patient sample. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIAID

Mild cases of coronavirus disease 2019 (COVID-19) can trigger robust memory T cell responses, even in the absence of detectable virus-specific antibody responses, researchers report August 14 in the journal Cell. The authors say that memory T cell responses generated by natural exposure to or infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—the virus that causes COVID-19—may be a significant immune component to prevent recurrent episodes of severe disease.

“We are currently facing the biggest global health emerge...

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The secret of Lymph: How Lymph Nodes help Cancer Cells spread

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The study found that melanoma cells (above) pass through the lymph nodes and pick up a protective coating, allowing them to survive high levels of oxidative stress and go on to form distant tumors.

For decades, physicians have known that many kinds of cancer cells often spread first to lymph nodes before traveling to distant organs through the bloodstream. New research from Children’s Medical Center Research Institute at UT Southwestern (CRI) provides insight into why this occurs, opening up new targets for treatments that could inhibit the spread of cancer.

The study, published today in Nature, found melanoma cells that pass through the lymph nodes pick up a protective coating, allowing them to survive high levels of oxidative stress in the blood and go on to form distant tumors.

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