Category Health/Medical

Antioxidant in Mushrooms may relieve features of ‘Pregnancy Hypertension’

L-( )-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat ModelHypertension, 2020; 75 (2): 561 DOI: 10.1161/HYPERTENSIONAHA.119.13929

A new study in rats suggests that the natural antioxidant L-ergothioneine could alleviate the characteristics of pre-eclampsia. Pregnancy hypertension, or Pre-eclampsia, is a complex disorder of pregnancy. Treatment of elevated blood pressure can manage the condition in the mother, but in severe cases delivery is needed, which can present a major problem to the baby if it is born prematurely.

Now, research from the Department of Pharmacology & Therapeutics at University College Cork (UCC), the INFANT Centre at UCC and the University of Liverpool, as well as The Novo Nordis...

Read More

B cells may travel to Remote Areas of the Brain to improve Stroke Recovery

New UK research reveals that B cells may travel to remote areas of the brain to improve recovery after a stroke.
New UK research reveals that B cells may travel to remote areas of the brain to improve recovery after a stroke.

New University of Kentucky research shows that the immune system may target other remote areas of the brain to improve recovery after a stroke.

The study in mice, published in PNAS by researchers from UK’s College of Medicine, University of Texas Southwestern Medical Center and University of Pennsylvania reveals that after a stroke, B cells migrate to remote regions of the brain that are known to generate new neuronal cells as well as regulate cognitive and motor functions.

B cells can produce neurotrophins that regulate the development and growth of neurons in the brain...

Read More

Computer Simulations Visualize how DNA converts Cells into Stem Cells

The pioneer transcription factor Oct4 (blue) binds to the nucleosome (a complex of proteins (green) and the DNA (orange) wrapped around these proteins). Credit: Jan Huertas and Vlad Cojocaru, ©MPI Münster, ©Hubrecht Institute.

Researchers of the Hubrecht Institute (KNAW — The Netherlands) and the Max Planck Institute in Münster (Germany) have revealed how an essential protein helps to activate genomic DNA during the conversion of regular adult human cells into stem cells. Their findings are published in the Biophysical Journal.

Signalling in the cell to start or stop reading DNA happens through proteins called transcription factors. Identity changes happen naturally during development as cells transition from an undesignated cell to a specific cell type...

Read More

New ‘Universal’ Target for Antiviral Treatment

 A Requirement for Argonaute 4 in Mammalian Antiviral Defense. Cell Reports, 2020; 30 (6): 1690 DOI: 10.1016/j.celrep.2020.01.021

Researchers have uncovered a novel potential antiviral drug target that could lead to treatments protecting against a host of infectious diseases. As the coronavirus outbreak shows, viruses are a constant threat to humanity. Vaccines are regularly developed and deployed against specific viruses, but that process takes a lot of time, doesn’t help everyone who needs protection, and still leaves people exposed to new outbreaks and new viruses.

Now, researchers at Massachusetts General Hospital (MGH) have uncovered a novel potential antiviral drug target that could lead to treatments protecting against a host of infectious diseases – creating a pan, or u...

Read More