Category Health/Medical

Zebrafish teach Researchers more about Atrial Fibrillation

Stock photo of a zebrafish, which has not been part of the study. Photo: Colourbox
Stock photo of a zebrafish, which has not been part of the study. Photo: Colourbox

Researchers from the Faculty of Health and Medical Sciences have shown a possible link between a genetic variation and the widespread type of cardiac arrhythmia, atrial fibrillation.

The scientists conducted the study in zebrafish, which is a recognised scientific animal model within cardiac research.

Here, researchers from the University of Copenhagen in Denmark and the Max Planck Institute in Germany put special focus on the gene pitx2c. The result came as a surprise to them, says Assistant Professor Pia Lundegaard from the Department of Biomedical Sciences.

‘It seems that we may also have to think of atrial fibrillation as an atrial cardiomyopathy – that is, a challenged heart – rather than...

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Programmable Nests for Cells

2019_161_Programmierbare Nester fuer Zellen_72dpi
Bacteria cells (red) on a programmable composite of silica nanoparticles (yellow) and carbon nanotubes (blue). (Photo: Niemeyer-Lab, KIT)

Using DNA, smallest silica particles, and carbon nanotubes, researchers of Karlsruhe Institute of Technology (KIT) developed novel programmable materials. These nanocomposites can be tailored to various applications and programmed to degrade quickly and gently. For medical applications, they can create environments in which human stem cells can settle down and develop further. Additionally, they are suited for the setup of biohybrid systems to produce power, for instance. The results are presented in Nature Communications and on the bioRxiv platform.

Stem cells are cultivated for fundamental research and development of effective therapies agains...

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A Replacement for Exercise?

Exercise gear in a bottle
Sestrins are evolutionarily conserved mediators of exercise benefits
Nature Communications volume 11, Article number: 190 (2020)

A protein called Sestrin might be responsible for many of the benefits of a good workout. Michigan Medicine researchers studying a class of naturally occurring protein called Sestrin have found that it can mimic many of exercise’s effects in flies and mice. The findings could eventually help scientists combat muscle wasting due to aging and other causes.

“Researchers have previously observed that Sestrin accumulates in muscle following exercise,” said Myungjin Kim, Ph.D., a research assistant professor in the Department of Molecular & Integrative Physiology. Kim, working with professor Jun Hee Lee, Ph.D...

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A Replacement for Exercise?

Michigan Medicine researchers studying a class of naturally occurring protein called Sestrin have found that it can mimic many of exercise’s effects in flies and mice. The findings could eventually help scientists combat muscle wasting due to aging and other causes.

“Researchers have previously observed that Sestrin accumulates in muscle following exercise,” said Myungjin Kim, Ph.D., a research assistant professor in the Department of Molecular & Integrative Physiology. Kim, working with professor Jun Hee Lee, Ph.D. and a team of researchers wanted to know more about the protein’s apparent link to exercise. Their first step was to encourage a bunch of flies to work out.

Taking advantage of Drosophila flies’ normal instinct to climb up and out of a test tube, their collaborators Robert Wess...

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