Category Health/Medical

Discovery of Anti-Opioid Pathway offers New Route to designing Safer Pain Medications

Genetic behavioral screen identifies an orphan anti-opioid system. Science, 2019; eaau2078 DOI: 10.1126/science.aau2078

Innovative worm study provides new insights into genetics of addiction-prone drugs. A team at Scripps Research in Florida has discovered a biological system that manages cells’ response to opioid drug exposure. The unexpected discovery offers new ideas for improving the safety of the one of the most effective, and most abused, group of pain medications.

In a paper published as a “First Release,” in the journal Science, lead authors Kirill Martemyanov, PhD, and Brock Grill, PhD, describe how they designed and implemented a new, unbiased approach for decoding the genetic network that controls actions of opioids in a nervous system.

They used a small soil d...

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Tiny Lensless Endoscope captures 3D Images of Objects Smaller than a Cell

Researchers have developed a new self-calibrating endoscope that produces 3D images of objects smaller than a single cell.
Credit: J. Czarske, TU Dresden, Germany

Self-calibrating technology opens new opportunities for medicine and research. Researchers have developed a new self-calibrating endoscope that produces 3D images of objects smaller than a single cell. Without a lens or any optical, electrical or mechanical components, the tip of the endoscope measures just 200 microns across, about the width of a few human hairs twisted together.

As a minimally invasive tool for imaging features inside living tissues, the extremely thin endoscope could enable a variety of research and medical applications...

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New Pain Organ Discovered in the Skin

This shows a woman rubbing her shoulder
The cells that make up the organ are highly sensitive to mechanical stimuli, which explain how they can participate in the detection of painful pinpricks and pressure. The image is in the public domain.

Researchers at Karolinska Institutet in Sweden have discovered a new sensory organ that is able to detect painful mechanical damage, such as pricks and impacts. The discovery is being published in the journal ‘Science’.

Pain causes suffering and results in substantial costs for society. Almost one person in every five experiences constant pain and there is a considerable need to find new painkilling drugs. However, sensitivity to pain is also required for survival and it has a protective function...

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High-Fat Diet and Gut Bacteria Linked to Insulin Resistance

Gut-associated IgA immune cells regulate obesity-related insulin resistance. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-11370-y

Researchers have discovered how our choice of diet can weaken our gut immune system and lead to the development of diabetes. A growing body of research supports that during obesity, our immune system is often responding to components of bacteria that “leak” through the intestinal tissue and results in inflammation. In turn, inflammation can drive insulin resistance, which predisposes people to diabetes.

In new research published in Nature Communications this week, Dr...

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