Category Health/Medical

Take 2 E. coli and call me in the morning

When E. coli bacteria are exposed to a certain biological signal, the trigger element engineered into their DNA flips the memory element into an “on” state, allowing easy identification of bacteria that “remember” the presence of the signal. Credit: Wyss Institute at Harvard University

Synthetic bacterial memory circuits enable microbial diagnostics for sensing biomolecules in the gut...

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New Knowledge on the Development of Asthma

Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells

Researchers at Karolinska Institutet in Sweden have studied which genes are expressed in overactive immune cells in mice with asthma-like inflammation of the airways. Their results, which are published in the journal Immunity, suggest that the synthesis and breakdown of fats plays an important part in the process.

In asthma, the immune system is overactive, causing inflammation in the lungs and symptoms such as coughing, wheezing and shortness of breath. The Th2 cell plays a vital part in asthma-related inflammation, but the rarity of these cells and a lack of sensitivity technology has made these cells hard to study in any detail.

Resear...

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New Therapy Targets Gut Bacteria to Prevent and Reverse Food Allergies

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Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergyNature Medicine, 2019; DOI: 10.1038/s41591-019-0461-z

A new study identifies the species of bacteria in the human infant gut that protect against food allergies, finding changes associated with the development of food allergies and an altered immune response.

Every three minutes, a food-related allergic reaction sends someone to the emergency room in the U.S. Currently, the only way to prevent a reaction is for people with food allergies to completely avoid the food to which they are allergic. Researchers are actively seeking new treatments to prevent or reverse food allergies in patients...

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Could Coffee be the Secret to Fighting Obesity?

 Caffeine exposure induces browning features in adipose tissue in vitro and in vivoScientific Reports, 2019; 9 (1) DOI: 10.1038/s41598-019-45540-1

Scientists from the University of Nottingham have discovered that drinking a cup of coffee can stimulate ‘brown fat’, the body’s own fat-fighting defenses, which could be the key to tackling obesity and diabetes.

The pioneering study, published today in the journal Scientific Reports, is one of the first to be carried out in humans to find components which could have a direct effect on ‘brown fat’ functions, an important part of the human body which plays a key role in how quickly we can burn calories as energy.

Brown adipose tissue (BAT), also known as brown fat, is one of two types of fat found in humans and other mammals...

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