Category Health/Medical

‘Limitless Potential’ of Artificial Protein ushers in new era of ‘Smart’ cell therapies

Science illustration.
LOCKR in its closed (background) and open (foreground) states. A ‘key’ (black) unlocks a ‘cage’ (grey), revealing a bioactive peptide (yellow) which can interact with other molecules in the cell. More than a hundred million would be needed to cover the period at the end of this sentence. Credit: Ian Haydon / Institute for Protein Design at UW.

Transformative biotechnology lets scientists build biological circuits that give cells unprecedented capabilities. A first-of-its-kind artificial protein – designed on a computer and synthesized in the lab – can be used to build brand-new biological circuits inside living cells. These circuits transform ordinary cells into smart cells that are endowed with remarkable abilities.

Medicine has a “Goldilocks” problem...

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Genome Research shows that the Body controls the Integrity of Heritable Genomes

  1. Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ CellsDevelopmental Cell, 2019; 50 (2): 167 DOI: 10.1016/j.devcel.2019.06.012

Scientists have presented new findings that challenge established concepts of genetic inheritance. They have proven that somatic cells of the roundworm C. elegans influence heredity.

Scientists at the CECAD Cluster of Excellence in Aging Research of the University of Cologne have discovered that body cells which are in direct contact with the germ cells in the nematode Caenorhabditis elegans are responsible for controlling the stability of the genome in primordial germ cells (PGCs). All germ cells, including sperm and eggs, originate from primordial germ cells that form during early embryo development...

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New study explains the Molecular Mechanism for the Therapeutic Effects of Cilantro

Shown is a computer simulation of E-2-dodecenal (orange) docking in its predicted binding site on the neuronal KCNQ potassium channel.

Herbs, including cilantro, have long been used as folk remedies. Herbs, including cilantro, have a long history of use as folk medicine anticonvulsants. Until now, many of the underlying mechanisms of how the herbs worked remained unknown. In a new study, researchers uncovered the molecular action that enables cilantro to effectively delay certain seizures common in epilepsy and other diseases.

The study, published in FASEB Journal, explains the molecular action of cilantro (Coriandrum sativum) as a highly potent KCNQ channel activator. This new understanding may lead to improvements in therapeutics and the development of more efficacious drugs.

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Widespread Aspirin use despite Few Benefits, High Risks

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Prevalence of Aspirin Use for Primary Prevention of Cardiovascular Disease in the United States: Results From the 2017 National Health Interview SurveyAnnals of Internal Medicine, 2019; DOI: 10.7326/M19-0953

Medical consensus once supported daily use of low dose aspirin to prevent heart attack and stroke in people at increased risk for cardiovascular disease (CVD). But in 2018, three major clinical trials cast doubt on that conventional wisdom, finding few benefits and consistent bleeding risks associated with daily aspirin use...

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