Category Health/Medical

What Controls the Tips of our Chromosomes?

Telomeres (in green) are at the tips of chromosomes (in red).
Credit: Jose Escandell, IGC

The tips of our chromosomes have telomeres. They work as a protective cap that prevents our genetic material from unfolding and corroding away. When they do not work properly, telomeres can lead to the total erosion of our genetic material and can trigger cancer and age-related diseases. In a study now published in EMBO Journal, a research team from Instituto Gulbenkian de Ciencia (IGC; Portugal), led by Jose Escandell and Miguel Godinho Ferreira, discovered a key aspect of the regulation of telomeres.

There is an increasing number of human syndromes attributed to telomeres malfunction...

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Engineers create Rubbery ‘Smart’ Material to treat Open Wounds, Infections and Cancer

Professor James H. Henderson and Ph.D. candidate Shelby L. Buffington of Syracuse University display the new shape memory polymer in their lab.
Credit: Syracuse University

Researchers in the Syracuse University College of Engineering and Computer Science have developed a material – a new kind of shape memory polymer (SMP) – that could have major implications for health care.

SMPs are soft, rubbery, “smart” materials that can change shape in response to external stimuli like temperature changes or exposure to light. They can hold each shape indefinitely and turn back when triggered to do so.

SMPs have many potential biomedical applications...

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New Protein ‘Switch’ could be key to Controlling Blood-Poisoning and Preventing Death from Sepsis

Sepsis or septicaemia.

Scientists at the University of British Columbia have discovered a new protein “switch” that could stop the progression of blood-poisoning, or sepsis, and increase the chances of surviving the life-threatening disease.

Sepsis, an inflammatory disease that arises when the body’s response to an infection injures its own tissues and organs, causes an estimated 14 million deaths every year. In a study published recently in Immunity, researchers examined the role of a protein called ABCF1 in regulating the progression of sepsis.

“Sepsis triggers an uncontrolled chain-reaction of inflammation in the body, leading to tissue damage, organ failure, and death,” said Hitesh Arora, co-lead author of the study who conducted this research as a PhD student at the Michael Smith...

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Young Bone Marrow Rejuvenates Aging Mouse Brains

Microglia in brains of old mice have larger cell bodies with fewer and shorter branches than those in young mice. But microglia of old mice who received bone marrow transplants (BMT) from young mice resembled those of young mice; transplants from older mice didn’t have that effect. Microglia play an important role in brain health.
Credit: Cedars-Sinai / Communications Biology

Transplanting marrow from young lab mice to old mice preserves memory and learning skills. The findings support an emerging model that attributes cognitive decline, in part, to aging of blood cells, which are produced in bone marrow.

“While prior studies have shown that introducing blood from young mice can reverse cognitive decline in old mice, it is not well understood how this happens,” said Helen Goodridge, Ph...

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