Category Health/Medical

AI can predict Premature Death, study finds

Top 15 risk factor variables for predicting mortality listed in descending order of “importance” by algorithm derived from the training cohort of 376,971 patients.

Computers which are capable of teaching themselves to predict premature death could greatly improve preventative healthcare in the future, suggests a new study by experts at the University of Nottingham. The team of healthcare data scientists and doctors have developed and tested a system of computer-based ‘machine learning’ algorithms to predict the risk of early death due to chronic disease in a large middle-aged population.

They found this AI system was very accurate in its predictions and performed better than the current standard approach to prediction developed by human experts...

Read More

Discovery of Life-Extension Pathway in Worms demonstrates new way to Study Aging

Figure 2

Phenotypic screening identifies SH-directed inhibitors that extend lifespan in C. elegans.

New method could enable faster study of strategies to combat age-related diseases. An enzyme-blocking molecule can extend the lifespan of Caenorhabditis elegans roundworms by as much as 45%, largely by modulating a cannabinoid biological pathway, according to a study from scientists at Scripps Research.

The scientists, whose work is published on March 25 in Nature Chemical Biology, also showed that the lifespan-extending cannabinoid pathway in C. elegans is related in unexpected ways to cannabinoid pathways found in humans and other mammals.

“This study reveals a new life-extension pathway, but more broadly, it introduces a powerful method for applying chemical probes to lab animals such as worm...

Read More

CRISPR-chip enables Digital Detection of DNA without Amplification

Kiana Aran’s novel system immobilizes the CRISPR complexes on the surface of graphene-based transistors. These complexes search a genome to find their target sequence and, if the search is successful, bind to its DNA. This binding changes the conductivity of the graphene material in the transistor, which detects the change using a handheld reader.
Credit: Keck Graduate Institute (KGI)

Researchers have found multiple applications for the CRISPR gene editing technology since it came into use by the scientific community...

Read More

How does Estrogen Protect Bones? Unraveling a pathway to menopausal bone loss

Estrogen induces osteocyte expression of Sema3A, which acts on its receptor on osteocytes to promote survival, resulting in reduced osteoclastic bone resorption and enhanced osteoblastic bone formation. Sema3A-activated sGC-cGMP signaling through Nrp1 protected osteocytes from apoptosis.
Credit: Department of Cell Signaling,TMDU

Women who have reached menopause are at a greater risk of developing osteoporosis, which can lead to bone fractures and long-term impairment of mobility. Studies have suggested a link between reduced bone density and low estrogen levels due to menopause, but the basis for this link is unclear. Researchers found that the protein Sema3A plays a key role in maintaining healthy bones, suggesting a new therapeutic avenue to treat osteoporosis.

Bone is a complex...

Read More