Category Health/Medical

Researchers have found that the RNA-binding protein PUM2 contributes to the accumulation of defective mitochondria, a key feature of the aging process. Targeting PUM2 in old animals protects against age-related mitochondrial dysfunction...

Scientists have repurposed the gene-editing tool CRISPR to study which genes are targeted by particular antibiotics, providing clues on how to improve existing antibiotics or develop new ones. Resistance to current antibiotics by disease-causing pathogens is a growing problem, one estimated to endanger millions of lives and cost over $2 billion each year in the U.S. “What we need to do is to figure out new weaknesses in these bacteria,” says Jason Peters, a UW-Madison professor of pharmaceutical sciences, who developed the new system.

The technique, known as Mobile-CRISPRi, allows scientists to screen for antibiotic function in a wide range of pathogenic bacteria...

Carrying extra body fat, especially around the middle, may be linked to brain shrinkage, according to a study published in the Jan. 9, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology. For the study, researchers determined obesity by measuring body mass index (BMI) and waist-to-hip ratio in study participants and found those with higher ratios of both measures had the lowest brain volume.

BMI is a weight-to-height ratio. It is determined by dividing a person’s weight by the square of their height. People with a BMI above 30.0 are considered obese...

Transforming super-sensitive touch sensors, engineers and medical researchers build a way to wirelessly monitor blood flow after surgery. It is biodegradable, battery-free and wireless, so it is compact and doesn’t need to be removed and it can warn a patient’s doctor if there is a blockage.

“Measurement of blood flow is critical in many medical specialties, so a wireless biodegradable sensor could impact multiple fields including vascular, transplant, reconstructive and cardiac surgery,” said Paige Fox, assistant professor of surgery and co-senior author of the paper...