Category Health/Medical

Switch-in-a-Cell Electrifies Life


Rice University scientists used E. coli bacteria as a platform to test protein switches that can be used to control the flow of electrons. Proteins placed in cells can simply be turned on and off with chemical signals.
Credit: Illustration by Josh Atkinson/Rice University

Scientists create electrical protein switches triggered by chemicals. Scientists at Rice University have developed synthetic protein switches to control the flow of electrons.

The proof-of-concept, metal-containing proteins made in the Rice lab of synthetic biologist Joff Silberg are expressed within cells upon the introduction of one chemical and are functionally activated by another chemical. If the proteins have been placed in the cell, they can simply be turned on and off...

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Biodegradable, Edible Film Kills Pathogens on Seafood

seafood

“If you put the antimicrobial into an edible film, and then dip the shrimp into the film and pull it out, that film is going to form around the shrimp. The film then releases the antimicrobials over time,” said Catherine Cutter, professor of food science.
 IMAGE: © GETTY IMAGES / ALEX RATHS

A biodegradable, edible film made with plant starch and antimicrobial compounds may control the growth of foodborne pathogens on seafood, according to a group of international researchers. “We have the ability to develop a film with antimicrobial activity that can kill foodborne pathogens on food surfaces,” said Catherine Cutter, professor of food science, Penn State...

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Biologists turn Eavesdropping Viruses into Bacterial Assassins


These E. coli bacteria harbor proteins from the eavesdropping virus. One of the viral proteins has been tagged with a red marker. When the virus is in the ‘stay’ mode (left), the bacteria grow and the red protein is spread throughout each cell. When the virus overhears that its hosts have achieved a quorum (right), the kill-stay decision protein is flipped to ‘kill’ mode. A second viral protein binds the red protein and sends it to the cell poles (yellow dots). All the cells in the right panel will soon die.
Credit: Images courtesy of Bonnie Bassler and Justin Silpe, Department of Molecular Biology, Princeton University

How cross-kingdom communication led to a breakthrough phage therapy...

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Origins of Pain

painful shoulder

Researchers have identified the nerve-signaling pathway behind the deep, sustained pain that sets in following injury.

Researchers identify pathway that drives sustained pain following injury. Withdrawing one’s hand to avoid injury and soothing the pain of that injury are two distinct evolutionary responses, but their molecular origins and signaling pathways have eluded scientists thus far.

Now research led by investigators at Harvard Medical School, published Dec. 10 in Nature, identifies the nerve-signaling pathway behind the deep, sustained pain that sets in immediately following injury. The findings also shed light on the different pathways that drive reflexive withdrawal to avoid injury and the subsequent pain-coping responses.

Clinical observations of patients with neurolog...

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