Category Health/Medical

GS-5734 is effective against a diverse array of human and zoonotic CoV in HAE.
(A) Neighbor-joining trees created with representatives from all four CoV genogroups showing the genetic similarity of CoV nsp12 (RdRp) and CoV spike glycoprotein, which mediates host tropism and entry into cells. Text color of the virus strain label corresponds to virus host species on the left. The heatmap adjacent to each neighbor-joining tree depicts percent amino acid identity (% A.A. identity) against SARS-CoV or MERS-CoV.

A new antiviral drug candidate inhibits a broad range of coronaviruses, including the SARS and MERS coronaviruses. The findings support further development of the drug candidate for treating and preventing current coronavirus infections and potential future epidemic outbreaks.

Coronavirus...

“Air Pollution and Mortality in the Entire Medicare Population,” Qian Di, Yan Wang, Antonella Zanobetti, Yun Wang, Petros Koutrakis, Christine Choirat, Francesca Dominici, Joel D. Schwartz, New England Journal of Medicine, June 29, 2017, doi: 10.1056/NEJMoa1702747k

Study of US seniors Strengthens link between Air Pollution and Premature Death

A new study of 60 million Americans – about 97% of people age 65 and older in the US – shows that long-term exposure to airborne fine particulate matter (PM2.5) and ozone increases the risk of premature death, even when that exposure is at levels below the National Ambient Air Quality Standards (NAAQS) currently established by the U.S. Environmental Protection Agency.

The Harvard T.H...

Carbon nanofibers coated with PEDOT in a scanning electron microscope image. Credit: Juan Guzman and Meryem Pehlivaner/Provided

Cornell materials scientists and bioelectrochemical engineers may have created an innovative, cost-competitive electrode material for cleaning pollutants in wastewater. The researchers created electro-spun carbon nanofiber electrodes and coated them with a conductive polymer, called PEDOT, to compete with carbon cloth electrodes available on the market. When the PEDOT coating is applied, an electrically active layer of bacteria – Geobacter sulfurreducens – naturally grows to create electricity and transfer electrons to the novel electrode...

Georgia Tech’s Regents Professor Mostafa El-Sayed (front) is one of the most highly decorated and cited living chemists. With his team for this research from left to right: Yue Wu, Professor Ronghu Wu, and Yan Tang. Credit: Georgia Tech / Christopher Moore

Researchers have found a way to virtually halt cell migration, a key component in metastasis, in vitro, in human cells. In past in vivo studies in mice, treated cancer did not appear to recur. No significant side effects were observed. Cancer cells often cover themselves bristly leg-like protrusions that enable them to creep. The researchers have used minuscule gold rods heated gently by a laser to mangle the protrusions, according to a new study.

The treatment can also easily kill cancer cells, but in this experiment, it was vital to sp...