Category Health/Medical

PNPLA1 is involved in acylceramide synthesis.

The gene responsible for generating acylceramide, the key lipid in forming the skin barrier that protects us from pathogens, allergens and other harmful substances. This finding could prove crucial in developing medicines for treating atopic dermatitis and ichthyosis. Defects of the skin barrier can trigger skin diseases such as atopic dermatitis, which afflicts ~10% of the population in some developed countries. Acylceramide, a lipid only found in skin, plays a pivotal role in forming this barrier. Although most of the genes needed to generate this special lipid have been recently identified, the gene responsible in the final step to produce acylceramide has been missing...

Amorphous silicon core inside a 1.7-micron inner-diameter glass capillary Image: Penn State

A new method to improve semiconductor fiber optics may lead to a material structure that might one day revolutionize the global transmission of data, according to an interdisciplinary team. Researchers are working with semiconductor optical fibers, which hold significant advantages over silica-based fiber optics, the current technology used for transmitting nearly all digital data. Silica – glass – fibers can only transmit electronic data converted to light data. This requires external electronic devices that are expensive and consume enormous amounts of electricity...

A team of biomedical engineering researchers has created a revolutionary 3D-bioprinted patch that can help heal scarred heart tissue after a heart attack. Two of the researchers involved are biomedical engineering Associate Professor Brenda Ogle (right) and Ph.D. student Molly Kupfer (left). Credit: Patrick O’Leary, University of Minnesota

A team of biomedical engineering researchers, led by the University of Minnesota, has created a revolutionary 3D-bioprinted patch that can help heal scarred heart tissue after a heart attack. The discovery is a major step forward in treating patients with tissue damage after a heart attack. The research study is published in Circulation Research, a journal published by the American Heart Association. Researchers have filed a patent on the discovery.

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The Cas13a enzyme causes collateral RNA damage that is the heart of a new diagnostic system, SHERLOCK, that can detect minute quantities of virus and much more

Researchers have created a version of CRISPR-Cas that can be used to diagnose infections, such as Zika and dengue, with a high level of sensitivity. The advancement could help facilitate rapid detection and diagnosis of many other pathogens, too. While some methods exist for detecting genetic sequences, they have trade-offs among sensitivity, specificity, simplicity, cost, and speed. In the search for a more effective method, Feng Zhang, Jonathan S. Gootenberg and colleagues turned to a CRISPR-Cas system that targets RNA.

Binding the target RNA activates this particular Cas enzyme to promiscuously cleave nearby RNA...