Category Health/Medical

Construction of a tissue-specific protein abundance atlas. (a) Vascularized organs, plasma and cells adjacent to the blood plasma were collected from healthy Balb-C mice. The collected organs and cells were washed in PBS, homogenized, the proteins digested with trypsin and analysed by shotgun LC-MS/MS. (b) The scaled spectral counts from the LC-MS/MS analysis of the individual organs and cells were correlated using Pearson’s r correlation coefficient, indicated by the numbers in the heat map. (c) Heat map of the scaled spectral counts of the different cell and organs. The grey lines in the heat map shows percentage of signal associated with a given organ or cell type. Total number of identified proteins per organ, blood vessel and cells is shown in brackets below the heat map.

Research g...

Mapping of cortical fold depths. In green: sulcal pits (the deepest point of each fold). In red: localization of the abnormality detected in autistic children (in Broca’s area). Credit: © SCALP team / INT

Scientists have identified a cerebral marker specific to autism that can be detected by MRI present from 2 yo. The abnormality consists in a less deep fold in Broca’s area, a region of the brain specialized in language and communication, functions that are impaired in autistic patients. This discovery may assist in the earlier diagnosis and management of these patients...

Life-extending hormone bolsters the body’s immune function. Credit: Yale University

A hormone that extends lifespan in mice by 40% is produced by specialized cells in the thymus gland, according to a new study by Yale School of Medicine researchers. The team also found that increasing the levels of this hormone, called FGF21, protects against the loss of immune function that comes with age. The study’s findings have future implications for improving immune function in the elderly, for obesity, and for illnesses such as cancer and type-2 diabetes.

When functioning normally, the thymus produces new T cells for the immune system, but with age, the thymus becomes fatty and loses its ability to produce new T cells...

Exercise, alone or in combination with education, may reduce the risk of low back pain, a meta-analysis and review of medical literature suggests. Daniel Steffens, Ph.D., of the University of Sydney, Australia, and coauthors identified 23 published reports (on 21 different randomized clinical trials including 30,850 participants) that met their inclusion criteria.

Moderate-quality evidence suggests exercise combined with education reduces the risk of an episode of low back pain and low- to very low-quality evidence suggests exercise alone may reduce the risk of both a low back pain episode and the use of sick leave. Other interventions, including education alone, back belts and shoe inserts do not appear to be associated with the prevention of low back pain.

“Although our review found evi...