Category Health/Medical

These are neurons (c-fos, green) in the rat central amygdala activated by E. coli proteins in stationary phase and surrounded by nerve terminals (calcitonin gene-related peptide, red) originating from anorexigenic brainstem projections. Credit: J. Breton, N. Lucas & D. Schapman.

Don’t have room for dessert? The bacteria in your gut may be telling you something. 20 min after a meal, gut microbes produce proteins that can suppress food intake in animals, reports a study. The researchers also show how these proteins injected into mice and rats act on the brain reducing appetite, suggesting that gut bacteria may help control when and how much we eat.

The new evidence coexists with current models of appetite control, which involve hormones from the gut signalling to brain circuits when we’re hu...

Self-repaired supergel supports its own weight after being sliced in half. Credit: Image courtesy of University of Texas at Austin

Researchers in the Cockrell School of Engineering at The University of Texas at Austin have developed a first-of-its-kind self-healing gel that repairs and connects electronic circuits, creating opportunities to advance the development of flexible electronics, biosensors and batteries as energy storage devices.

Although technology is moving toward lighter, flexible, foldable and rollable electronics, the existing circuits that power them are not built to flex freely and repeatedly self-repair cracks or breaks that can happen from normal wear and tear...

Figure shows the way that copies of the toxin pack together to form pores in cells. Credit: University of Leicester

It gives hope for developing Rx for pneumococcal diseases such as bacterial pneumonia, meningitis and septicaemia. The 3 yr study involving 4 research groups from across the University has been described as an exciting advance because it points to the possibility of creating therapeutics that block assembly of pneumolysin pores to treat people with pneumococcal disease.

Using X-ray crystallography at Diamond Light Source, UK’s national synchrotron science facility, the Leicester team was able to see the individual atoms of the toxin. The structure not only reveals what the toxin looks like, but also shows how it assembles on the surface of cells to form lethal pores...

In comparison to other organs, the human brain has the highest energy requirements. Credit: Image courtesy of University of Zurich

They show for the 1st time in the intact mouse brain evidence for an exchange of lactate between different brain cells. With this study they were able to confirm a 20-year old hypothesis. In comparison to other organs, the human brain has the highest energy requirements. A hypothesis from the 1990’s postulates, that a well-orchestrated collaboration between astrocytes and neurons, is the basis of brain energy metabolism.

Astrocytes produce lactate, which flows to neurons to cover their high energy needs. Due to a lack of experimental techniques, it remained unclear whether an exchange of lactate existed between astrocytes and neurons...