Category Health/Medical

Tubulin prevents toxic protein clumps in the brain, fighting back against neurodegeneration

Tubulin prevents toxic protein clumps in the brain, fighting back neurodegeneration
WT Tau/αSyn Endogenous Colocalization in Cells and Tau/αSyn/Tubulin Confocal Phase Diagram. Credit: Nature Communications (2026). DOI: 10.1038/s41467-026-69618-3

Researchers at Baylor College of Medicine have discovered a potential new strategy to fight back against Alzheimer’s and Parkinson’s diseases, conditions that are linked to the toxic accumulation of Tau and alpha synuclein protein clumps in the brain. The team reports in Nature Communications that tubulin, the building block of microtubules, the cell’s internal ‘railway tracks,” can stop Tau and alpha synuclein from forming toxic clumps and instead steer them into their normal, healthy roles.

“Tau and alpha synuclein are well known for their roles in neurodegenerative diseases like Alzheimer’s and Parkinson’s...

Read More

AAOS: GLP-1 receptor agonist use increases five-year risk for osteoporosis

AAOS: GLP-1 receptor agonist use increases five-year risk for osteoporosis

Treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for type 2 diabetes and obesity is independently associated with a significantly increased five-year risk for osteoporosis, gout, and osteomalacia compared with nonuse, according to a study presented at the annual meeting of the American Academy of Orthopaedic Surgeons, held from March 2 to 6 in New Orleans.

Muaaz Wajahath, from the Michigan State University College of Human Medicine in East Lansing, and colleagues evaluated the five-year risk for osteoporosis, gout, and osteomalacia in adults with both type 2 diabetes and obesity treated with GLP-1 RAs (semaglutide, liraglutide, dulaglutide, or exenatide) compared with matched controls (73,483 per group).

The researchers found that at five years, patients expo...

Read More

A safer, more effective atrial fibrillation treatment method using magnetic gel may be on the way

A safer, more effective atrial fibrillation treatment method using magnetic fluids may be on the way
Complete LAAO using magnetofluids and comparisons between the magnetogel and the Watchman occluder. Credit: Nature (2026). DOI: 10.1038/s41586-025-10091-1

Atrial fibrillation is a common heart condition characterized by a rapid, irregular heartbeat stemming from the heart’s upper chamber. It is a leading cause of stroke from clots that form in a small pouch of the heart called the left atrial appendage (LAA). While several treatment options exist, they have many drawbacks, and risks often remain. But now, researchers have developed a promising new treatment involving magnetic fluids. Their study, published in Nature, describes the new procedure and results from rat and pig studies.

Atrial fibrillation treatment options
Blood thinners are a common treatment for atrial fibrillation...

Read More

Injectable ‘satellite livers’ could offer an alternative to liver transplantation

Researchers used a microfluidic device to generate hydrogel microspheres of uniform shape and size. These spheres are then mixed with hepatocytes and injected into the body, where they form stable mini livers.
Credits:Credit: Courtesy of the Bhatia Lab

More than 10,000 Americans who suffer from chronic liverdisease are on a waitlist for a liver transplant, but there are not enough donated organs for all of those patients. Additionally, many people with liver failure aren’t eligible for a transplant if they are not healthy enough to tolerate the surgery.

To help those patients, MIT engineers have developed “mini livers” that could be injected into the body and take over the functions of the failing liver.

In a new study in mice, the researchers showed that these injected liver cell...

Read More