Category Health/Medical

Spontaneous knee effusion, also known as ‘water on the knee,’ can be a primary symptom of Lyme disease, even when patients do not exhibit a ‘bull’s eye’ rash, another common Lyme disease symptom. According to a literature review, early diagnosis and antibiotic treatment can prevent the development of Lyme disease’s more severe symptoms.

Lyme borreliosis, or Lyme disease–the most common vector-borne illness transmitted by insects–is prevalent in the Northeast and upper Midwest regions of the United States. Over 30,000 cases are reported to CDC each year and likely over 300,000 new cases occur but go unreported.

“It is important to catch and treat Lyme disease early because the symptoms get progressively worse over time,” said Elizabeth Matzkin, MD...

The gene Prkci promotes the generation of differentiated cells (red). However if Prkci activity is reduced or absent, neural stem cells (green) are promoted. Credit: In Kyoung Mah

When it comes to stem cells, too much of a good thing isn’t wonderful: producing too many new stem cells may lead to cancer; producing too few inhibits the repair and maintenance of the body. Medical researchers now describe a key gene in maintaining this critical balance between producing too many and too few stem cells.

Prkci is the gene influences whether stem cells self-renew to produce more stem cells, or differentiate into more specialized cell types, such as blood or nerves. In their experiments, the team grew mouse embryonic stem cells, which lacked Prkci, into embryo-like structures in the laboratory...

Image: Dr Nuno Reis demonstrates how the disposable microfluidic test strip works.

Academics hope to boost early detection rates of cancer in developing countries with their portable lab-in-a-briefcase that can operate even at high temperatures. Believed to be the 1st kit of its kind dedicated to the portable measurement of cancer biomarkers, the concept is the brainchild of Dr Nuno Reis, a Lecturer in Chemical Engineering.

The number of people dying from cancer in developing countries is on the increase, partly due to steadily ageing populations, but also due to limited access to proper diagnostic tools. Cancer is a leading cause of death worldwide, accounting for >8 million deaths/ yr, and 70% of the world’s cancer deaths occur in Africa, Asia and Central and South America...

Highlights •CK2 is preferentially activated in white fat by norepinephrine and under obesity •CK2 inhibition in white fat activates thermogenesis in response to cAMP stimuli •CK2 inhibition increases UCP1-dependent energy expenditure in vivo •CK2 inhibition ameliorates diet-induced obesity and insulin resistance

Drugs that flip this switch rapidly reduced obesity and diabetes risk factors in mice fed a high fat diet. The results suggest that drugs capable of targeting similar molecular pathways in human fat cells could one day become major tools for fighting the growing worldwide epidemics of obesity and type 2 diabetes.

All mammals, including humans, have two types of fat with completely opposite functions: white, which stores energy and is linked with diabetes and obesity; and br...