fMRI signals in the brain’s visual cortex as an individual views the checkerboard stimulus. The green, blue and dark blue spots represent signals produced within a fraction of a second after stimulation with dark blue being the fastest responding areas. Source: Lewis, et al.2
By significantly increasing the speed of fMRI, researchers have been able to image rapidly fluctuating brain activity during human thought. fMRI measures changes in blood oxygenation, which were previously thought to be too slow to detect the subtle neuronal activity associated with higher order brain functions. The new discovery that fast fMRI can detect rapid brain oscillations is a significant step towards realizing a central goal of neuroscience research: mapping brain networks responsible for human cognitive functions eg perception, attention, awareness.
“A critical aim of the President’s BRAIN Initiative is to move neuroscience into a new realm where we can identify and track functioning neural networks non-invasively,” explains Guoying Liu, Ph.D., Director of the NIBIB program in Magnetic Resonance Imaging. “This work demonstrates the potential of fMRI for mapping healthy neural networks as well as those that may contribute to neurological diseases such as dementia and other mental health disorders, which are significant national and global health problems.”
fMRI works by detecting local increases in oxygen as blood is delivered to a working part of the brain. The technique has been instrumental for identifying which areas in the brain control functions such as vision, hearing, or touch. However, standard fMRI can only detect the blood flow coming to replenish an area of the brain several seconds after it has performed a function. It was generally accepted that this was the limit of what could be detected by fMRI – identification of a region in the brain that had responded to a large stimulus, such as a continuous 30 second “blast” of bright light.
Combining several new techniques, Jonathan R. Polimeni, Ph.D. et al at Harvard’s Athinoula A. Martinos Center for Biomedical Imaging, applied fast fMRI in an effort to track neuronal networks that control human thought processes, and found that they could now measure rapidly oscillating brain activity. They used fast fMRI in volunteers observing a rapidly fluctuating checkerboard pattern. The fast fMRI was able to detect the subtle and very rapid oscillations in cerebral blood flow in the brain’s visual cortex as the volunteers observed the changing pattern.
“The oscillating checkerboard pattern is a more “naturalistic” stimulus, in that its timing is similar to the very subtle neural oscillations made during normal thought processes,” explains Polimeni. “The fast fMRI detects the induced neural oscillations that allow the brain to understand what the eye is observing — the changing checkerboard pattern. These subtle oscillations were completely undetectable with standard fMRI.”
Laura D. Lewis, Ph.D. said: “This technique now gives us a method for obtaining much more detailed information about the complex brain activity that takes place during sleep, as well as other dynamic switches in brain states, such as when under anesthesia and during hallucinations.”
Concludes Polimeni, “It had always been thought that fMRI had the potential to play a major role in these types of studies. Meaningful progress in cognitive neuroscience depends on mapping patterns of brain activity, which are constantly and rapidly changing with every experience we have. Thus, we are extremely excited to see our work contribute significantly to achieving this goal.” https://www.nibib.nih.gov/news-events/newsroom/imaging-technique-can-see-you-think
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