Injectable Porous Scaffolds Promote Better, Quicker Healing after Spinal Cord Injuries

Images show myelinated axons in biomaterial scaffolds eight weeks after injection into the injured cord of a mouse. Scaffolds were fabricated from hyaluronic acid (HA) with a regular network of cell-scale macropores and loaded with gene therapy vectors encoding for brain-derived neurotrophic factor (BDNF), to promote axonal survival and regeneration. These were compared to control scaffolds, which were lacking the BDNF vector. Images show dense infiltration of cells (shown in blue, cell nuclei), axons (shown in red in A, NF200 protein) and myelinating glial cells (shown in green, myelin basic protein) in the BDNF-laden scaffolds. Scale bars = 200 µm. CREDIT: Seidlits et al.
Images show myelinated axons in biomaterial scaffolds eight weeks after injection into the injured cord of a mouse. 

Hydrogel scaffolds with regularly spaced pores encourage spinal cords cells to grow, improve regeneration of nerve cells. Researchers have developed materials that can interface with an injured spinal cord and provide a scaffolding to facilitate healing. To do this, scaffolding materials need to mimic the natural spinal cord tissue, so they can be readily populated by native cells in the spinal cord, essentially filling in gaps left by injury. The researchers show how the pores improve efficiency of gene therapies administered locally to the injured tissues, which can further promote tissue regeneration.

Spinal cord injuries can be life-changing and alter many importa...

Read More

‘Wearable microgrid’ uses the human body to sustainably power small gadgets

White long sleeve shirt with electronics printed onto it
The wearable microgrid uses energy from human sweat and movement to power an LCD wristwatch and electrochromic device. Photos by Lu Yin

Nanoengineers at the University of California San Diego have developed a “wearable microgrid” that harvests and stores energy from the human body to power small electronics. It consists of three main parts: sweat-powered biofuel cells, motion-powered devices called triboelectric generators, and energy-storing supercapacitors. All parts are flexible, washable and can be screen printed onto clothing.

The technology, reported in a paper published Mar. 9 in Nature Communications, draws inspiration from community microgrids.

“We’re applying the concept of the microgrid to create wearable systems that are powered sustainably, reliably and independently...

Read More

A Giant, Sizzling Planet may be Orbiting the Star Vega

Vega is the fifth brightest star, excluding the sun, that can be seen from Earth. (Credit: CC image by Stephen Rahn via Wikimedia Commons)

Astronomers have discovered new hints of a giant, scorching-hot planet orbiting Vega, one of the brightest stars in the night sky. The research, published this month in The Astrophysical Journal, was led by University of Colorado Boulder student Spencer Hurt, an undergraduate in the Department of Astrophysical and Planetary Sciences.

It focuses on an iconic and relatively young star, Vega, which is part of the constellation Lyra and has a mass twice that of our own sun. This celestial body sits just 25 light-years, or about 150 trillion miles, from Earth—pretty close, astronomically speaking.

Scientists can also see Vega with telescopes even...

Read More

New Inhibitor found to combat Drug-resistant Cancer Cells

cancer
Credit: Pixabay/CC0 Public Domain

A new substance could improve the treatment of persistent cancers. Researchers at Martin Luther University Halle-Wittenberg (MLU) and the University of Greifswald have developed a new inhibitor that makes drug-resistant tumour cells respond again to chemotherapy. The new substance blocks a protein in the cancer cells that normally transports the cancer drugs back out of the cells. The results were published in the scientific journal Molecules.

In addition to radiation therapy, cytotoxic agents, also known as chemotherapy, are frequently used to treat cancer. They prevent cells from dividing and thus cancer cells are unable to multiply unchecked...

Read More