New Potential Therapy for Crohn’s disease in Children

High magnification micrograph of Crohn’s disease. Biopsy of esophagus. H&E stain. Credit: Nephron/Wikipedia

Scientists from the Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago demonstrated that a nanotherapy reduces intestinal inflammation and shrinks lesions in a rodent model of severe Crohn’s disease. This approach could become an alternative to biologic antibody therapies that carry many side effects, including increased risk of certain cancers. It might also prevent the need for surgery in the future. Findings were published in the journal Advanced Therapeutics.

Crohn’s disease is an inflammatory bowel disease characterized by chronic inflammation of the digestive tract, most often in the small intestine...

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A Speed Limit also applies in the Quantum world

A speed limit also applies in the quantum world
First author Manolo Rivera Lam (left) and principal investigator Dr. Andrea Alberti (right) at the Institute of Applied Physics at the University of Bonn. Credit: © Volker Lannert/Uni Bonn

Even in the world of the smallest particles with their own special rules, things cannot proceed infinitely fast. Physicists at the University of Bonn have now shown what the speed limit is for complex quantum operations. The study also involved scientists from MIT, the universities of Hamburg, Cologne and Padua, and the Jülich Research Center. The results are important for the realization of quantum computers, among other things. They are published in the prestigious journal Physical Review X, and covered by the Physics Magazine of the American Physical Society.

Suppose you observe a waiter (the...

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Cold Dust Cores in the Central Zone of the Milky Way

The Milky Way’s central molecular zone (CMZ) spans the innermost 1600 light-years of the galaxy (for comparison, the Sun is 26,600 light-years away from the galactic center) and includes a vast complex of molecular clouds containing about sixty million solar-masses of molecular gas. The gas in these clouds exists under more extreme physical conditions than elsewhere in the galaxy on average, with higher densities and temperatures, more intense pressures, magnetic fields, and turbulence, and higher cosmic-ray abundances and ultraviolet and X-ray radiation...

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Gut Microbiome implicated in Healthy Aging and Longevity

gut
Credit: CC0 Public Domain

Data from over 9,000 people reveal a distinct gut microbiome signature that is associated with healthy aging and survival in the latest decades of life. The gut microbiome is an integral component of the body, but its importance in the human aging process is unclear. ISB researchers and their collaborators have identified distinct signatures in the gut microbiome that are associated with either healthy or unhealthy aging trajectories, which in turn predict survival in a population of older individuals. The work is set to be published in the journal Nature Metabolism.

The research team analyzed gut microbiome, phenotypic and clinical data from over 9,000 people — between the ages of 18 and 101 years old — across three independent cohorts...

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