How a Longevity Gene protects Brain Stem Cells from Stress

cells under a microscope
Antioxidant treatment boosts the birth of new neurons from stem cells by suppressing stress signaling. Image courtesy of the Paik lab.

A gene linked to unusually long lifespans in humans protects brain stem cells from the harmful effects of stress, according to a new study by Weill Cornell Medicine investigators.

Studies of humans who live longer than 100 years have shown that many share an unusual version of a gene called Forkhead box protein O3 (FOXO3). That discovery led Dr. Jihye Paik, associate professor of pathology and laboratory medicine at Weill Cornell Medicine, and her colleagues to investigate how this gene contributes to brain health during aging.

In 2018, Dr...

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New Potential Therapy for Crohn’s disease in Children

High magnification micrograph of Crohn’s disease. Biopsy of esophagus. H&E stain. Credit: Nephron/Wikipedia

Scientists from the Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago demonstrated that a nanotherapy reduces intestinal inflammation and shrinks lesions in a rodent model of severe Crohn’s disease. This approach could become an alternative to biologic antibody therapies that carry many side effects, including increased risk of certain cancers. It might also prevent the need for surgery in the future. Findings were published in the journal Advanced Therapeutics.

Crohn’s disease is an inflammatory bowel disease characterized by chronic inflammation of the digestive tract, most often in the small intestine...

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A Speed Limit also applies in the Quantum world

A speed limit also applies in the quantum world
First author Manolo Rivera Lam (left) and principal investigator Dr. Andrea Alberti (right) at the Institute of Applied Physics at the University of Bonn. Credit: © Volker Lannert/Uni Bonn

Even in the world of the smallest particles with their own special rules, things cannot proceed infinitely fast. Physicists at the University of Bonn have now shown what the speed limit is for complex quantum operations. The study also involved scientists from MIT, the universities of Hamburg, Cologne and Padua, and the Jülich Research Center. The results are important for the realization of quantum computers, among other things. They are published in the prestigious journal Physical Review X, and covered by the Physics Magazine of the American Physical Society.

Suppose you observe a waiter (the...

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Cold Dust Cores in the Central Zone of the Milky Way

The Milky Way’s central molecular zone (CMZ) spans the innermost 1600 light-years of the galaxy (for comparison, the Sun is 26,600 light-years away from the galactic center) and includes a vast complex of molecular clouds containing about sixty million solar-masses of molecular gas. The gas in these clouds exists under more extreme physical conditions than elsewhere in the galaxy on average, with higher densities and temperatures, more intense pressures, magnetic fields, and turbulence, and higher cosmic-ray abundances and ultraviolet and X-ray radiation...

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