Breaking bad: How Shattered Chromosomes make Cancer Cells Drug-Resistant

In this scanning electron micrograph of inside the nucleus of a cancer cell, chromosomes are indicated by blue arrows and circular extra-chromosomal DNA are indicated by orange arrows. Image courtesy of Paul Mischel, UC San Diego.

Scientists describe how a phenomenon known as ‘chromothripsis’ breaks up chromosomes, which then reassemble in ways that ultimately promote cancer cell growth.

In a paper published in the December 23, 2020 online issue of Nature, researchers at University of California San Diego School of Medicine and the UC San Diego branch of the Ludwig Institute for Cancer Research, with colleagues in New York and the United Kingdom, describe how a phenomenon known as “chromothripsis” breaks up chromosomes, which then reassemble in ways that ultimately promote cancer ce...

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DeepMind’s MuZero Conquers and Learns the rules as it does

game
Credit: Unsplash/CC0 Public Domain

Albert Einstein once said, “You have to learn the rules of the game, and then you have to play better than anyone else.” That could well be the motto at DeepMind, as a new report reveals it has developed a program that can master complex games without even knowing the rules.

DeepMind, a subsidiary of Alphabet, has previously made groundbreaking strides using reinforcement learning to teach programs to master the Chinese boardgame Go and the Japanese strategy game Shogi, as well as chess and challenging Atari video games. In all those instances, computers were given the rules of the game.

But Nature reported today that DeepMind’s MuZero has accomplished the same feats—and in some instances, beat the earlier programs—without first learning the rul...

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Recently discovered Comet seen during 2020 total Solar Eclipse

(left) The LASCO C2 camera on the ESA/NASA SOHO observatory shows comet C/2020 X3 (SOHO) in the bottom left-hand corner. (right) A composite image of the total solar eclipse on Dec. 14, 2020, based on 65 frames taken by Andreas Möller (Arbeitskreis Meteore e.V.) in Piedras del Aguila, Argentina, and processed by Jay Pasachoff and Roman Vanur.
Credits: ESA/NASA/SOHO/Andreas Möller (Arbeitskreis Meteore e.V.)/processed by Jay Pasachoff and Roman Vanur/Joy Ng. Eclipse image used with permission.

As Chile and Argentina witnessed the total solar eclipse on Dec. 14, 2020, unbeknownst to skywatchers, a little tiny speck was flying past the Sun — a recently discovered comet.

This comet was first spotted in satellite data by Thai amateur astronomer Worachate Boonplod on the NASA-funded Sung...

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New class of Antibiotics active against a Wide Range of Bacteria

Dual-acting immuno-antibiotics block an essential pathway in bacteria and activate the adaptive immune response. Wistar Institute scientists have discovered a new class of compounds that uniquely combine direct antibiotic killing of pan drug-resistant bacterial pathogens with a simultaneous rapid immune response for combatting antimicrobial resistance (AMR). These finding were published today in Nature.

The World Health Organization (WHO) has declared AMR as one of the top 10 global public health threats against humanity. It is estimated that by 2050, antibiotic-resistant infections could claim 10 million lives each year and impose a cumulative $100 trillion burden on the global economy...

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