New Anti-AB Vaccine could help Halt Alzheimer’s Progression, preclinical study finds

In the Alzheimer’s disease brain, the amyloid beta peptide clumps together to form hardened plaques between nerve cells.

A preclinical study by neuroscientists indicates that an antigen-presenting dendritic vaccine with a specific antibody response to oligomeric A-beta may be safer and offer clinical benefit in treating Alzheimer’s disease. The vaccine uses immune cells known as dendritic cells loaded with a modified A beta peptide as the antigen.

A preclinical study by neuroscientists indicates that an asntigen-presenting dendritic vaccine with a specific antibody response to oligomeric A-beta may be safer and offer clinical benefit in treating Alzheimer’s disease. The vaccine uses immune cells known as dendritic cells loaded with a modified A beta peptide as the antigen.

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Colorful Perovskites: Thermochromic Window Technologies

Photo of a researcher holding a sample of perovskite window technology
NREL researcher Lance Wheeler holds samples of perovskite-based window technology. Photo by Dennis Schroeder, NREL

Research developments create faster changes at lower temperatures, more colors. Scientists at the U.S. Department of Energy’s National Renewable Energy Laboratory (NREL) report a breakthrough in developing a next-generation thermochromic window that not only reduces the need for air conditioning but simultaneously generates electricity.

Heat generated by sunlight shining through windows is the single largest contributor to the need for air conditioning and cooling in buildings. Because residential and commercial buildings use 74% of all electricity and 39% of all energy in the United States, the shading effect from tinting windows helps buildings use less energy.

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Evidence of Broadside Collision with Dwarf Galaxy discovered in Milky Way

The Milky Way’s Shell Structure Reveals the Time of a Radial Collision
Thomas Donlon II, Heidi Jo Newberg, Robyn Sanderson, Lawrence M. Widrow

‘Shell structures’ are first of their kind found in the galaxy. Nearly 3 billion years ago, a dwarf galaxy plunged into the center of the Milky Way and was ripped apart by the gravitational forces of the collision. Astrophysicists announced today that the merger produced a series of telltale shell-like formations of stars in the vicinity of the Virgo constellation, the first such “shell structures” to be found in the Milky Way. The finding offers further evidence of the ancient event, and new possible explanations for other phenomena in the galaxy.

Astronomers identified an unusually high density of stars called the Virgo Overdensity about ...

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Restoration of Retinal and Visual Function following Gene Therapy

Base editing restores vision
A mutation in an inherited blindness mouse model abolishes the expression of RPE65, a key enzyme in a visual cycle, in the RPE cells. Base editing treatment can correct the mutation and restore functional RPE65 (green), thereby restoring vision in mice

New generation CRISPR technology lays foundation for therapeutics to treat a wide range of inherited ocular diseases. A breakthrough study, led by researchers from the University of California, Irvine, results in the restoration of retinal and visual functions of mice models suffering from inherited retinal disease.

Published today in Nature Biomedical Engineering, the paper, titled, “Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing,” illustrates the use of a new generation CRISPR...

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