Glioblastoma Nanomedicine crosses into Brain in mice, Eradicates recurring brain Cancer

Macroscopic pathology of glioblastoma multiforme. Image credit: CC BY-SA 4.0 – Sbrandner

A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier in mice could deliver cancer-killing drugs directly to malignant brain tumors, new research from the University of Michigan shows. ‘I’ve worked in this field for more than 10 years and have not seen anything like this.’

The study is the first to demonstrate an intravenous medication that can cross the blood-brain barrier.

The discovery could one day enable new clinical therapies for treating glioblastoma, the most common and aggressive form of brain cancer in adults, and one whose incidence is rising in many countries...

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Researchers 3D print Biomedical Parts with Supersonic Speed

Cells adhering to titanium alloy
This image shows cells adhering to a titanium alloy created by cold-spray 3D printing, which demonstrates the material’s biocompatibility.

Forget glue, screws, heat or other traditional bonding methods. A Cornell University-led collaboration has developed a 3D printing technique that creates cellular metallic materials by smashing together powder particles at supersonic speed.

This form of technology, known as “cold spray,” results in mechanically robust, porous structures that are 40% stronger than similar materials made with conventional manufacturing processes. The structures’ small size and porosity make them particularly well-suited for building biomedical components, like replacement joints.

The team’s paper, “Solid-State Additive Manufacturing of Porous Ti-6Al-4V by Supe...

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Researchers 3D print Biomedical Parts with Supersonic Speed

Cells adhering to titanium alloy
This image shows cells adhering to a titanium alloy created by cold-spray 3D printing, which demonstrates the material’s biocompatibility.

Forget glue, screws, heat or other traditional bonding methods. A Cornell University-led collaboration has developed a 3D printing technique that creates cellular metallic materials by smashing together powder particles at supersonic speed.

This form of technology, known as “cold spray,” results in mechanically robust, porous structures that are 40% stronger than similar materials made with conventional manufacturing processes. The structures’ small size and porosity make them particularly well-suited for building biomedical components, like replacement joints.

The team’s paper, “Solid-State Additive Manufacturing of Porous Ti-6Al-4V by Supe...

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Researchers Model Source of Eruption on Jupiter’s moon Europa

This artist’s conception of Jupiter’s icy moon Europa shows a hypothesized cryovolcanic eruption, in which briny water from within the icy shell blasts into space. A new model of this process on Europa may also explain plumes on other icy bodies. (Image credit: Justice Blaine Wainwright)

On Jupiter’s icy moon Europa, powerful eruptions may spew into space, raising questions among hopeful astrobiologists on Earth: What would blast out from miles-high plumes? Could they contain signs of extraterrestrial life? And where in Europa would they originate? A new explanation now points to a source closer to the frozen surface than might be expected.

Rather than originating from deep within Europa’s oceans, some eruptions may originate from water pockets embedded in the icy shell itself, ...

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