Engineered Killer Immune Cells Target Tumors and their Immunosuppressive Allies

D-L1 CAR haNKs demonstrated superior killing of murine HNSCC targets compared to haNKs.

Scientists have engineered natural killer immune cells that not only kill head and neck tumour cells in mice but also reduce the immune-suppressing myeloid cells that allow tumours to evade the immune response, according to a new study in eLife.

The engineered cell therapy could be used as an alternative approach for treating cancer in patients for whom previous immunotherapy based on the activation of T cells has failed. These findings are reported by researchers at the U.S. National Institutes of Health (NIH) in Bethesda, Maryland.

In recent years, treatments called T-cell therapy or CAR-T cell therapy have been approved to treat blood cancers, and many others are now in development for othe...

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Engineers use Electricity to Clean up Toxic Water

Researchers from the School of Chemical and Biomolecular Engineering developed an electrochemical oxidation process with the aim of cleaning up complex wastewater that contained a toxic cocktail of chemical pollutants.

“Our study, published in Algal Research, involved industrial wastewater that had been heavily contaminated with a cocktail of organic and inorganic species during a biofuel production process,” said Julia Ciarlini Jungers Soares, who is completing a PhD in Chemical and Biomolecular Engineering under the supervision of Dr Alejandro Montoya.

The wastewater, which contained carbon, nitrogen and phosphorus, was generated in a pilot plant, designed by the team for the production of biofuels using naturally abundant microalgae.

The process involved treating wastewate...

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The Collective Power of the Solar System’s Dark, Icy Bodies

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Scientists have long struggled to explain the existence of the solar system’s “detached objects,” which have orbits that tilt like seesaws and often cluster in one part of the night sky. (Credit: Steven Burrows/JILA)

Two new studies by researchers at the University of Colorado Boulder may help to solve one of the biggest mysteries about the dark, icy bodies of the outer solar system: why so many of them don’t circle the sun the way they should.

The outermost reaches of our solar system are a strange place – filled with dark and icy bodies with nicknames like Sedna, Biden and The Goblin, each of which span several hundred miles across.

The orbits of these planetary oddities, which scientists call “detached objects,” tilt and buckle out of the plane of the solar system, amon...

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Age-related Impairments Reversed in Animal Model

With age the frequency of adipose tissue eosinophils decreases gradually. This leads to the production of inflammatory mediators, which promote age-related impairments (e.g. frailty and immunosenescence). Eosinophil cell transfers increase the frequency of these cells in adipose tissue and dampen age-related chronic low-grade inflammation. This results in systemic rejuvenation of the aged organism. © DBMR, University of Bern, D. Brigger

Frailty and immune decline are two main features of old age. Researchers now demonstrate in an animal model that these two age-related impairments can be halted and even partially reversed using a novel cell-based therapeutic approach.

Elderly people are more prone to infectious diseases as the function of their immune system continuously declines w...

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