Trial Drug can significantly Block Early stages of COVID-19 in engineered human tissues

In cell cultures analyzed in the current study, hrsACE2 inhibited the coronavirus load by a factor of 1,000-5,000. Credit: IMBA/Tibor Kulcsar

An international team led by University of British Columbia researcher Dr. Josef Penninger has found a trial drug that effectively blocks the cellular door SARS-CoV-2 uses to infect its hosts.

The findings, published today in Cell, hold promise as a treatment capable of stopping early infection of the novel coronavirus that, as of April 2, has affected more than 981,000 people and claimed the lives of 50,000 people worldwide.

The study provides new insights into key aspects of SARS-CoV-2, the virus that causes COVID-19, and its interactions on a cellular level, as well as how the virus can infect blood vessels and kidneys.

“We are hopefu...

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Electron-eating Neon causes Star to Collapse

An artist’s impression shows how an imaginary neon footballfish eats away at the electrons inside a star core. Credit: Kavli IPMU

An international team of researchers has found that neon inside a certain massive star can consume the electrons in the core, a process called electron capture, which causes the star to collapse into a neutron star and produce a supernova.

The researchers were interested in studying the final fate of stars within a mass range of eight to 10 solar masses, or eight to 10 times the mass of the sun. This mass range is important because it includes the boundary between whether a star has a large enough mass to undergo a supernova explosion to form a neutron star, or has a smaller mass to form a white dwarf star without becoming a supernova.

An eight- to 1...

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‘Tequila’ powered Biofuels more Efficient than Corn or Sugar

Associate Professor Daniel Tan in Ayr, Queensland, in front of agave plants.
Associate Professor Daniel Tan in Ayr, Queensland, in front of agave plants.

Ethanol from agave could be used for transport fuel and hand sanitizer. The agave plant used to make tequila could be established in semi-arid Australia as an environmentally friendly solution to Australia’s transport fuel shortage, a team of researchers at the University of Sydney, University of Exeter and University of Adelaide has found.

The efficient, low-water process could also help produce ethanol for hand sanitiser, which is in high demand during the COVID-19 pandemic.

In an article published this week in the Journal of Cleaner Production, University of Sydney agronomist Associate Professor Daniel Tan with international and Australian colleagues have analysed the potential to produce bioethanol (...

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Advances in production of Retinal Cells for treating Blindness

Retinal cells stained for the identified surface marker CD140b in green (image from Fredrik Lanner’s research group)

Researchers at Karolinska Institutet and St Erik Eye Hospital in Sweden have discovered a way to refine the production of retinal cells from embryonic stem cells for treating blindness in the elderly. Using the CRISPR/Cas9 gene editing, they have also managed to modify the cells so that they can hide from the immune system to prevent rejection. The studies are published in the scientific journals Nature Communications and Stem Cell Reports.

Age-related macular degeneration of the eye is the most common cause of blindness in the elderly...

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