Tiny Scorpion-derived Proteins deliver Arthritis Drugs to Joints in preclinical study

An Israeli death scorpion
More than a decade ago, Olson discovered a mini-protein found in the deathstalker scorpion that can bind to cancer cells but not healthy ones.Getty Images

Scientists at Fred Hutchinson Cancer Research Center identified a tiny protein in scorpion venom that rapidly accumulates in joint cartilage. Then they linked these mini-proteins with steroids to reverse inflammation in rats with arthritis. The researchers found that the drugs concentrated in the joints, potentially avoiding the body-wide toxicities and infection risks caused by nontargeted steroid treatment.

“For people with multi-joint arthritis, the side effects of controlling the disease can be as bad or worse than the disease itself,” said the project’s senior scientist Dr...

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A Flexible Brain for AI

Improved integration density: Comparison in integration density @[2020] IEEE. International Solid-State Circuits Conference

Scientists have developed a customizable computing device using nanofabricated switches than can be rewired to optimize AI applications using 80% less power. These devices can be used as flexible computing platform for artificial intelligence tasks.

Scientists at Osaka University built a new computing device from field-programmable gate arrays (FPGA) that can be customized by the user for maximum efficiency in artificial intelligence applications. Compared with currently used rewireable hardware, the system increases circuit density by a factor of 12. Also, it is expected to reduce energy usage by 80%...

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Cosmic Impact caused Destruction of one of World’s Earliest Human Settlements

Before the Taqba Dam impounded the Euphrates River in northern Syria in the 1970s, an archaeological site named Abu Hureyra bore witness to the moment ancient nomadic people first settled down and started cultivating crops. A large mound marks the settlement, which now lies under Lake Assad.

But before the lake formed, archaeologists were able to carefully extract and describe much material, including parts of houses, food and tools — an abundance of evidence that allowed them to identify the transition to agriculture nearly 12,800 years ago. It was one of the most significant events in our Earth’s cultural and environmental history.

Abu Hureyra, it turns out, has another story to tell...

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Yale Study may help Resolve Bitter Debate over Low-Cal Sweeteners

A diet soda with a green okay sign, and diet soda with fries under a red No sign
Illustration by Michael S. Helfenbein

A new study showed that people who periodically drank beverages with the low-calorie sweetener sucralose, which is found in low-cal soft drinks, candy, breakfast bars, and other products, did experience problematic metabolic and neural responses – but only when a carbohydrate in the form of a tasteless sugar was added to the drink. In contrast, people drinking beverages with low-calorie sweeteners alone, or beverages with real sugar, showed no changes in brain or metabolic response to sugars.

Several studies in recent years have reported that low-calorie sweeteners in foods and beverages disrupt the human , promoting the development of diabetes and obesity...

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