Scientists found a hidden flaw in prostate cancer’s survival system. Researchers have discovered that prostate cancer depends on two key enzymes, PDIA1 and PDIA5, to survive and resist therapy. When blocked, these enzymes cause the androgen receptor to collapse, killing cancer cells and enhancing the effects of drugs like enzalutamide. They also disrupt the cancer’s energy system, striking it on multiple fronts...

In an MIT classroom, a professor lectures while students diligently write down notes they will reread later to study and internalize key information ahead of an exam.

Humans know how to learn new information, but large language models can’t do this in the same way. Once a fully trained LLM has been deployed, its “brain” is static and can’t permanently adapt itself to new knowledge.

This means that if a user tells an LLM something important today, it won’t remember that information the next time this person starts a new conversation with the chatbot.

Now, a new approach developed by MIT researchers enables LLMs to update themselves in a way that permanently internalizes new information...

A nearby super-Earth may be one of the best chances yet to search for life beyond our solar system. A newly detected super-Earth just 20 light-years away is giving scientists one of the most promising chances yet to search for life beyond our solar system. The discovery of the exoplanet orbiting in the habitable zone of its star was made possible by advanced spectrographs designed at Penn State and by decades of observations from telescopes around the world.

A possible “supe...

A team of researchers has found a way to turn the bacteria living in the digestive tracts of animals into factories that can produce compounds that promote longevity in their hosts—showing a potential new drug development strategy.

Janelia Senior Group Leader Meng Wang and her team study longevity and were interested in seeing how they could transfer their research findings about longevity-promoting compounds into practical applications.

One idea they had was to induce the body’s gut microbiota—a collection of bacteria in th...