Repurposed Drugs may help scientists Fight the New Coronavirus


M protease (model shown) is a key enzyme for the new corona­virus’ survival and may be an Achilles’ heel. Drugs (blue) might be able to nestle into the enzyme and stop viral replication. DAVID S. GOODSELL/RCSB PROTEIN DATA BANK

Work on similar viruses is giving researchers clues to develop drugs against the disease. As the new coronavirus makes its way around the world, doctors and researchers are searching for drugs to treat the ill and stop the spread of the disease, which has already killed more than 3,800 people since its introduction in Wuhan, China, in December.

The culprit virus is in the same family as the coronaviruses that caused two other outbreaks, severe acute respiratory syndrome and Middle East respiratory syndrome...

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Ultrathin Organic Solar Cell is both Efficient and Durable

Ultra-thin organic solar cell

Scientists from the RIKEN Cluster for Pioneering Research and RIKEN Center for Emergent Matter Science have succeeded, in collaboration with international partners, in creating an ultrathin organic solar cell that is both highly efficient and durable. Using a simple post-annealing process, they created a flexible organic cell that degrades by less than 5 percent over 3,000 hours in atmospheric conditions and that simultaneously has an energy conversion ratio – a key indicator of solar cell performance – of 13 percent.

Organic photovoltaics are considered to be a promising alternative to silicon-based conventional films, being more environmentally friendly and cheap to produce...

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Astronomers use Slime Mold Model to reveal Dark Threads of the Cosmic Web

This intricate filamentary network (above) is a reconstruction of the cosmic web created by feeding data on the locations and masses of 37,000 galaxies into an algorithm based on the growth patterns of a slime mold. The images below are expanded views of small regions, showing the underlying galaxies on the left and, on the right, the filaments of the cosmic web superimposed on the galaxies.

The problem-solving prowess of a simple slime mold has been harnessed to trace the large-scale structure of the universe. A computational approach inspired by the growth patterns of a bright yellow slime mold has enabled a team of astronomers and computer scientists at UC Santa Cruz to trace the filaments of the cosmic web that connects galaxies throughout the universe.

Their results, publishe...

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Tiny Scorpion-derived Proteins deliver Arthritis Drugs to Joints in preclinical study

An Israeli death scorpion
More than a decade ago, Olson discovered a mini-protein found in the deathstalker scorpion that can bind to cancer cells but not healthy ones.Getty Images

Scientists at Fred Hutchinson Cancer Research Center identified a tiny protein in scorpion venom that rapidly accumulates in joint cartilage. Then they linked these mini-proteins with steroids to reverse inflammation in rats with arthritis. The researchers found that the drugs concentrated in the joints, potentially avoiding the body-wide toxicities and infection risks caused by nontargeted steroid treatment.

“For people with multi-joint arthritis, the side effects of controlling the disease can be as bad or worse than the disease itself,” said the project’s senior scientist Dr...

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