New ‘Universal’ Target for Antiviral Treatment

 A Requirement for Argonaute 4 in Mammalian Antiviral Defense. Cell Reports, 2020; 30 (6): 1690 DOI: 10.1016/j.celrep.2020.01.021

Researchers have uncovered a novel potential antiviral drug target that could lead to treatments protecting against a host of infectious diseases. As the coronavirus outbreak shows, viruses are a constant threat to humanity. Vaccines are regularly developed and deployed against specific viruses, but that process takes a lot of time, doesn’t help everyone who needs protection, and still leaves people exposed to new outbreaks and new viruses.

Now, researchers at Massachusetts General Hospital (MGH) have uncovered a novel potential antiviral drug target that could lead to treatments protecting against a host of infectious diseases – creating a pan, or u...

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Globular Cluster system of NGC 4546 studied in detail

Image g′ of the central region of NGC 4546 after the subtraction of its surface brightness. Credit: Escudero et al., 2020.

Using the Gemini-South telescope, astronomers have performed a photometric study of the lenticular galaxy NGC 4546. Results of the new research provide more clues about the structure and nature of the galaxy’s globular cluster system. The study was published February 7 on arXiv.org.

Globular clusters (GCs) are collections of tightly bound stars orbiting galaxies. Astronomers perceive them as natural laboratories enabling studies on the evolution of stars and galaxies...

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Mending a Broken Heart, the Bioengineering way

Electroconductive Melt Electrowritten Patches Matching the Mechanical Anisotropy of Human Myocardium. Advanced Functional Materials, 2020; 1909880 DOI: 10.1002/adfm.201909880

Bioengineers from Trinity College Dublin, Ireland, have developed a prototype patch that does the same job as crucial aspects of heart tissue. Their patch withstands the mechanical demands and mimics the electrical signalling properties that allow our hearts to pump blood rhythmically round our bodies.

Their work essentially takes us one step closer to a functional design that could mend a broken heart.

One in six men and one in seven women in the EU will suffer a heart attack at some point in their lives. Worldwide, heart disease kills more women and men – regardless of race, than any other disease.

C...

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Mars: Simulations of Early Impacts produce a Mixed Mars Mantle

Early Mars after impact, showing projectile materials leaving the planet
Courtesy of Southwest Research Institute A Southwest Research Institute team performed high-resolution, smoothed-particle simulations of a large, differentiated projectile hitting early Mars after its core and mantle had formed. The projectile’s core and mantle particles are indicated by brown and green spheres respectively, showing local concentrations of the projectile materials assimilated into the Martian mantle.

The early solar system was a chaotic place, with evidence indicating that Mars was likely struck by planetesimals, small protoplanets up to 1,200 miles in diameter, early in its history...

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