Targeting a Blood Stem Cell subset shows lasting, Therapeutically Relevant Gene Editing

Microscopy image of blood stem cells that will go through CRISPR/Cas9 gene editing in a lab dish. Credit: Kiem lab / Fred Hutchinson Cancer Research Center

Researchers at Fred Hutchinson Cancer Research Center used CRISPR-Cas9 to edit long-lived blood stem cells to reverse the clinical symptoms observed with several blood disorders, including sickle cell disease and beta-thalassemia. It’s the first time that scientists have specifically edited the genetic makeup of a specialized subset of adult blood stem cells that are the source of all cells in the blood and immune system.

The proof-of-principle study suggests that efficient modification of targeted stem cells could reduce the costs of gene-editing treatments for blood disorders and other diseases while decreasing the risks of u...

Read More

Experiments Explore the Mysteries of ‘Magic’ Angle Superconductors

Depiction of graphene
A team led by Princeton physicist Ali Yazdani has shown that strong electron interactions play a key role in the superconductivity that has been discovered in graphene, a material made up of single-layer sheets of carbon atoms. Here, two graphene sheets stacked on each other with a twist make a long-wavelength moiré pattern.
Image designed by Kai Fu for the Yazdani Lab, Princeton University

Physicists conducted experiments to explore superconductivity in a groundbreaking new material known as magic-angle twisted graphene. The team imaged electrons on the material’s surface and found that electrons interact with each other in ways that could help explain how superconductivity arises in this material.

In spring 2018, the surprising discovery of superconductivity in a new material s...

Read More

The Moon is Older than Previously Believed

This image shows what the collision between Earth and Theia might have looked like. Image: Hagai Perets
This image shows what the collision between Earth and Theia might have looked like. Image: Hagai Perets

Fifty years after the first landing on the Moon, scientists have combined new geochemical information to determine the Moon’s age using samples from different Apollo missions. After the formation of the solar system, 4.56 billion years ago, the Moon formed approximately 4.51 billion years ago. The new study has thus determined that the Moon is significantly older than previously believed – earlier research had estimated the Moon to have formed approximately 150 million years after solar system’s formation. To achieve these results, the scientists analysed the chemical composition of a diverse range of samples collected during the Apollo missions...

Read More

Antioxidant compound from Soybeans may prevent Marijuana-induced Blood Vessel Damage

Image result for Antioxidant compound from Soybeans may prevent Marijuana-induced Blood Vessel Damage
soybeans Antioxidant compound from Soybeans may prevent Marijuana-induced Blood Vessel Damage

In laboratory tests, a compound found in soybeans blocked damage to the lining of blood vessels in the heart and circulatory system and may someday provide a way to prevent the cardiovascular side effects of recreational and medical marijuana use, according to preliminary research presented at the American Heart Association’s Basic Cardiovascular Sciences 2019 Scientific Sessions.

Marijuana is the most widely used illicit drug worldwide and is increasingly being made legal for recreational and medicinal purposes. However, there have been studies that link marijuana smoking to an increased risk of heart attack and stroke...

Read More