Chemical Synthesis Breakthrough holds promise for Future Antibiotics

Graphical abstract: Total synthesis of micrococcin P1 and thiocillin I enabled by Mo(vi) catalyst

 Total synthesis of micrococcin P1 and thiocillin I enabled by Mo(vi) catalystChemical Science, 2019; DOI: 10.1039/C8SC04885A

University of Colorado Boulder chemistry researchers have developed a novel way to synthesize and optimize a naturally-occurring antibiotic compound that could one day be used to fight lethal drug-resistant infections such as Staphylococcus aureus, commonly known as MRSA.

Antibiotic-resistant infections afflict over 2 million people annually and result in over 23,000 deaths in the U.S. each year, according to the Centers for Disease Control and Prevention (CDC). A 2018 study by the CDC’s European counterpart found that drug-resistant superbugs were responsible for 33,000 deaths across Europe in 2015.

Researchers have previously identified thiopepti...

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The Coolest Experiment in the Universe


The International Space Station, shown here in 2018, is home to many scientific experiments, including NASA’s Cold Atom Laboratory.
Credit: NASA

The Cold Atom Lab (CAL) is the first facility in orbit to produce clouds of “ultracold” atoms, which can reach a fraction of a degree above absolute zero: -459ºF (-273ºC), the absolute coldest temperature that matter can reach. Nothing in nature is known to hit the temperatures achieved in laboratories like CAL, which means the orbiting facility is regularly the coldest known spot in the universe.

NASA’s Cold Atom Laboratory on the International Space Station is regularly the coldest known spot in the universe...

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Scientists Program Proteins to Pair exactly


Illustration of paired proteins that look like a DNA model


Technique paves the way for the creation of protein nanomachines and for engineering of new cell functions. Proteins have now been designed in the lab to zip together in much the same way that DNA molecules zip up to form a double helix. The technique, whose development was led by University of Washington School of Medicine scientists, could enable the design of protein nanomachines that can potentially help diagnose and treat disease, allow for the more exact engineering of cells and perform a wide variety of other tasks.

“For any machine to work, its parts must come together precisely,” said Zibo Chen, the lead author of the paper and a UW graduate student in biochemistry...

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Sound Waves Levitate Multiple Objects


Researcher testing the acoustic traps generated by the Holographic Acoustic TweezersSergio Larripa, Asier Marzo, Bruce Drinkwater © 2018

Future technology for contactless medical procedures. In the perhaps not so distant future, surgeons could perform a range of medical procedures all without touching the patient, thanks to advancements in ‘acoustic tweezers’.

Surgeons won’t be shrunk and sent into the body like in the 1960s Sci-Fi, Fantastic Voyage, but could program a specialised array of mini-speakers to create an intricate sound field that ‘traps’ and manipulates selected objects in ‘acoustic tweezers’ for manipulation within tissue.

Advancements in acoustic tweezers from Professor Bruce Drinkwater in the Department of Mechanical Engineering, University of Bristol, and his...

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