Leakage of the vascular tracer (red) from dermal blood vessels (green) in systemic inflammation.
Credit: Laura Hakanpaa / Saharinen Lab.

Increased capillary permeability and subsequent leakage from the capillaries is associated with numerous difficult-to-cure diseases, including acute respiratory distress syndrome (ARDS), severe Dengue fever and malaria, and sepsis. Currently, there is no effective therapy to inhibit capillary leakage and to maintain vessel stability in these diseases. The latest research published in the Proceedings of the National Academy of Sciences indicates that a monoclonal antibody targeted against β1-integrin inhibits vascular leakage in a mouse model of sepsis.

Integrins are heterodimeric cell surface receptors that mediate interactions between cells and the surro...

UCLA scientists developed artificial T cells that, like natural T cells, can deform to squeeze between tiny gaps in the body, as shown in this schematic.
Credit: Fatemeh Majedi

Discovery could be a step toward developing treatments for cancer and autoimmune diseases. UCLA researchers have developed synthetic T lymphocytes, or T cells, that are near-perfect facsimiles of human T cells. The ability to create the artificial cells could be a key step toward more effective drugs to treat cancer and autoimmune diseases and could lead to a better understanding of human immune cells’ behavior. Such cells also could eventually be used to boost the immune system of people with cancer or immune deficiencies.

The research team comprised scientists from the UCLA School of Dentistry, the UCLA Samueli Sch...

Excitation spectra of the Higgs mode

Researchers produce a state in which atoms behave similarly to a Higgs boson. Physicists at the University of Bonn have succeeded in putting a superconducting gas into an exotic state. Their experiments allow new insights into the properties of the Higgs particle, but also into fundamental characteristics of superconductors.

For their experiments, scientists at the University of Bonn used a gas made of lithium atoms, which they cooled down significantly. At a certain temperature, the state of the gas changes abruptly: It becomes a superconductor that conducts a current without any resistance. Physicists also speak of a phase transition. A similar sudden change occurs with water when it freezes.

The lithium gas changes to a more orderly state at its phas...

Range of the size for a typical neutron star compared to the city of Frankfurt. Credit: Lukas Weih, Goethe University, satellite image: GeoBasis-DE/BKG (2009) Google

Comparison of billions of theoretical models with gravitational waves results in the answer to an old riddle. How large is a neutron star? Previous estimates varied from eight to sixteen kilometres. Astrophysicists at the Goethe University Frankfurt and the FIAS have now succeeded in determining the size of neutron stars to within 1.5 kilometres by using an elaborate statistical approach supported by data from the measurement of gravitational waves. The researchers’ report appears in the current issue of Physical Review Letters.

Neutron stars are the densest objects in our universe, with a mass larger than that of our sun comp...