You may have heard of the fantastic-sounding “dark side of the genome.” This poorly studied fraction of DNA, known as heterochromatin, makes up around half of your genetic material, and scientists are now starting to unravel its role in your cells.

For more than 50 years, scientists have puzzled over the genetic material contained in this “dark DNA.” But there’s a growing body of evidence showing that its proper functioning is critical for maintaining cells in a healthy state. Heterochromatin contains tens of thousands of units of dangerous DNA, known as “transposable elements” (or TEs)...

Researchers at Columbia Engineering have for the first time used DNA to help create 3D electronically operational devices with nanometer-size features.

“Going from 2D to 3D can dramatically increase the density and computing power o...

NASA’s Perseverance rover landed on Mars in 2021 to search for signs of ancient microbial life and to help scientists understand the planet’s climate and geography. But another key objective is to pave the way for human exploration of Mars, and as part of that effort, the rover carries a set of five spacesuit material samples. Now, after those samples have endured four years of exposure on Mars’ dusty, radiation-soaked surface, scientists are beginning the next phase of studying them.

The end goal is to predict accurately the usable lifetime of a Mars spacesuit. What the agency learns about how the materials perform on Mars will inform the design of future spacesuits for the first astronauts on the red planet.

“This is one of the forward-looking aspects of the rover’s mission—no...

The mammalian immune system is an evolutionary wonder. It’s capable of recognizing and destroying cancer cells, and it can deploy armies of antibodies against viruses, bacteria, parasites and fungi.

Among the lesser-spotlighted roles of the immune system is how a particular T cell helps maintain homeostasis—fostering a balanced and stable metabolic environment—in fat cells. It’s a role that has captured the investigatory eye of an elite team of immunologists.

Having a stronger understanding of the dynamic metabolic activities and signaling pathways in fat tissue can aid new strategies to treat obesity, a major global health concern...