Interactive 3-D models of human joints, showing how common medical complaints have arisen and how we are likely to evolve in the future, have been created at Oxford University.

Interactive 3D models of human joints, showing how common medical complaints have arisen and how we are likely to evolve in the future, have been created at Oxford University. The Oxford researchers made the 3D computer models by compiling 128 slice CT scans of bones from humans, early hominids, primates and dinosaurs. In all, they scanned 224 bone specimens, spanning 350 million years from the Devonian period to the modern day.
By using 3-D engineering and mathematical methods the group has produced 3-D ‘morphs’ to plot changes in the shapes of species throughout the human lineage...

An artist’s rendition of 2016 WF9 as it passes Jupiter’s orbit inbound toward the sun. Credits: NASA/JPL-Caltech

NASA’s NEOWISE mission has recently discovered some celestial objects traveling through our neighborhood, including one on the blurry line between asteroid and comet. Another—definitely a comet—might be seen with binoculars through next week. An object called 2016 WF9 was detected by the NEOWISE project on Nov. 27, 2016. It’s in an orbit that takes it on a scenic tour of our solar system. At its farthest distance from the sun, it approaches Jupiter’s orbit. Over the course of 4.9 Earth-years, it travels inward, passing under the main asteroid belt and the orbit of Mars until it swings just inside Earth’s own orbit. After that, it heads back toward the outer solar system...

Micrograph showing prostatic acinar adenocarcinoma (the most common form of prostate cancer) Credit: Wikipedia

A new study led by scientists from TSRI, Florida sheds light on a signaling circuit in cells that drives therapy resistance in prostate cancer. Targeting the components of this circuit suppresses advanced prostate cancer development. Prostate cancer—which, according to the American Cancer Society, affects 1 in 6 American men—is the second-leading cause of death after lung cancer in American men.

Currently, the most effective treatment of advanced prostate cancer is to deprive the cancer of what feeds it—androgen hormones such as testosterone...

Highlights •Bacteriophage anti-CRISPR proteins inactivate Listeria monocytogenes CRISPR-Cas9 •Half of L. monocytogenes isolates possess inhibited CRISPR-Cas9 systems •AcrIIA2 and AcrIIA4 prevent target binding by dCas9 in bacteria •AcrIIA2 and AcrIIA4 inhibit Cas9-mediated gene editing in human cells

UCSF researchers have discovered a way to switch off the CRISPR-Cas9 gene-editing system using newly identified anti-CRISPR proteins that are produced by bacterial viruses. The technique has the potential to improve the safety and accuracy of CRISPR applications both in the clinic and for basic research...