Researchers at Duke University and North Carolina State University have discovered a handful of new CRISPR-Cas systems that could add to the capabilities of the already transformational gene editing and DNA manipulation toolbox.

Of the new recruits, one system from bacteria commonly found in dairy cows shows particular promise for human health. Its efficiency is on par with the original and most widely used CRISPR-Cas system, but its small size allows it to be more easily packaged for delivery to human cells. It also can target specific gene sequences that other systems cannot, and human immune systems are unlikely to have been exposed to it.

The results appear online March 14 in the Proceedings of the National Academy of Sciences (PNAS).

CRISPR-Cas9 burst onto the broader sc...

-Advancing the search for weird life on weird planets

Scientists have identified a promising new way to detect life on faraway planets, hinging on worlds that look nothing like Earth and gases rarely considered in the search for extraterrestrials.

In a new Astrophysical Journal Letters paper, researchers from the University of California, Riverside, describe these gases, which could be detected in the atmospheres of exoplanets – planets outside our solar system – with the James Webb Space Telescope, or JWST.

Called methyl halides, the gases comprise a methyl group, which bears a carbon and three hydrogen atoms, attached to a halogen atom such as chlo...

Keratinocytes produce collagen fibers, while deeper fibroblasts later modify the collagen fibers initially formed by keratinocytes. Challenging the long-standing belief that fibroblasts produce skin collagen, researchers at Okayama University have investigated collagen formation in the ‘glass-skinned’ amphibian axolotl and other vertebrates. They discovered that keratinocytes, the surface cells of the skin, are responsible for producing collagen, which is then transferred deeper to form the dermis. Later, fibroblasts migrate into this collagen layer, modifying and reinforcing its structure.

The skin consists of two primary layers...

Quantum holograms using polarized light and metasurfaces enable precise control over entangled holographic information, advancing practical applications in quantum communication and anticounterfeiting technologies

Quantum entanglement is a fundamental phenomenon in nature and one of the most intriguing aspects of quantum mechanics. It describes a correlation between two particles, such that measuring the properties of one instantly reveals those of the other, no matter how far apart they are. This unique property has been harnessed in applications such as quantum computing and quantum communication.

A common method for generating entanglement is through a nonlinear crystal, which produces photon pairs with entangled polarizations via spontaneous parametric down-conversion (SPDC)...