Novel Regulator of Immune Evasion in Cancer identified

Novel regulator of immune evasion in cancer identified
Representative images from immunohistochemical staining of PD-L1, ATXN3, IRF1, and HIF-2α in human lung adenocarcinoma (LUAD) and melanoma patients. Courtesy of Deyu Fang, PhD. Credit: Journal of Clinical Investigation (2023). DOI: 10.1172/JCI167728

Northwestern Medicine investigators have identified a previously unknown regulator of tumor immune evasion, which may help improve the efficacy of current and future antitumor immunotherapies, according to recent findings published in the Journal of Clinical Investigation.

“The study provides a molecular insight into understanding why some cancer patients cannot be treated by the checkpoint blockade antitumor therapy, but others can,” said Deyu Fang, Ph.D...

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New Fuel Cell Harvests Energy from Microbes in Soil to Power Sensors, Communications

New fuel cell harvests energy from microbes in soil to power sensors, communications
The clean fuel cell in the lab. Credit: Bill Yen/Northwestern University

A Northwestern University-led team of researchers has developed a new fuel cell that harvests energy from microbes living in dirt.

About the size of a standard paperback book, the completely soil-powered technology could fuel underground sensors used in precision agriculture and green infrastructure. This potentially could offer a sustainable, renewable alternative to batteries, which hold toxic, flammable chemicals that leach into the ground, are fraught with conflict-filled supply chains and contribute to the ever-growing problem of electronic waste.

To test the new fuel cell, the researchers used it to power sensors measuring soil moisture and detecting touch, a capability that could be valuable for track...

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Discovery of Second Ultra-Large Structure in Distant Space further Challenges Our Understanding of the Universe

Discovery of a second ultra-large structure in distant space further challenges what we understand about the universe
An artistic impression of what the Big Ring (shown in blue) and Giant Arc (shown in red) would look like in the sky. Credit: Stellarium

The Big Ring in the Sky is 9.2 billion light-years from Earth. It has a diameter of about 1.3 billion light-years, and a circumference of about 4 billion light-years. If we could step outside and see it directly, the diameter of the Big Ring would need about 15 full moons to cover it.

It is the second ultra-large structure discovered by University of Central Lancashire (UCLan) Ph.D. student Alexia Lopez who, two years ago, also discovered the Giant Arc in the Sky. Remarkably, the Big Ring and the Giant Arc, which is 3...

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Why is the Universe Ripping Itself Apart? A new study shows Dark Energy may be more complicated than we thought

A small star slurping material from a much larger one.
In a Type Ia supernova, a white dwarf slowly pulls mass from a neighboring star before exploding. NASA / JPL-CaltechCC BY

What is the universe made of? This question has driven astronomers for hundreds of years.

For the past quarter of a century, scientists have believed “normal” stuff like atoms and molecules that make up you, me, Earth, and nearly everything we can see only accounts for 5% of the universe. Another 25% is “dark matter”, an unknown substance we can’t see but which we can detect through how it affects normal matter via gravity.

The remaining 70% of the cosmos is made of “dark energy”. Discovered in 1998, this is an unknown form of energy believed to be making the universe expand at an ever-increasing rate.

In a new study soon to be published in the Astronom...

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