Researchers Identify ‘Switch’ to Activate Cancer Cell Death

A graphic shows two circles in blue and gold representing tumor cells and a red circle representing CAR-T immunotherapy.
An antigen-negative tumor cell, shown in the golden color on the right, is killed by Fas-mediated “bystander” killing.

A research team from the UC Davis Comprehensive Cancer Center has identified a crucial epitope (a protein section that can activate the larger protein) on the CD95 receptor that can cause cells to die. This new ability to trigger programmed cell death could open the door for improved cancer treatments. The findings were published Oct. 14 in the Nature journal Cell Death & Differentiation.

CD95 receptors, also known as Fas, are called death receptors. These protein receptors reside on cell membranes. When activated, they release a signal that causes the cells to self-destruct.

Modulating Fas may also extend the benefits of chimeric antigen receptor (CAR) T-cell th...

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Robots Learn Faster with AI Boost from Eureka

Robots learn faster with AI boost from Eureka
EUREKA generates human-level reward functions across diverse robots and tasks. Combined with curriculum learning, EUREKA for the first time, unlocks rapid pen-spinning capabilities on an anthropomorphicfive-finger hand. Credit: arXiv (2023). DOI: 10.48550/arxiv.2310.12931

Intelligent robots are reshaping our universe. In New Jersey’s Robert Wood Johnson University Hospital, AI-assisted robots are bringing a new level of security to doctors and patients by scanning every inch of the premises for harmful bacteria and viruses and disinfecting them with precise doses of germicidal ultraviolet light.

In agriculture, robotic arms driven by drones scan varying types of fruits and vegetables and determine when they are perfectly ripe for picking.

The Airspace Intelligence System AI Fly...

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Minerals in Ancient Meteorites offer Insights into the Origin of Most of the Earth’s Surface

meteorites
Credit: Pixabay/CC0 Public Domain

Dr. Alice Stephant, an astrophysicist, is helping to solve a longstanding mystery about water on Earth: where it came from.

Scientists long thought that water, which covers 70% of the Earth, is probably rare or non-existent on other planets. The assumption was that water on Earth resulted from a unique series of galactic events billions of years ago.

Stephant, who works at the National Institute of Astrophysics in Italy’s capital Rome, is challenging these longstanding assumptions.

She has produced research that suggests the chemical components of water—hydrogen and oxygen—could have come from the giant cloud of dust and gas that gave rise to Earth’s solar system.

If water from that cloud could go directly into forming planets, it could...

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Solar Farms in Space are possible

It’s viable to produce low-cost, lightweight solar panels that can generate energy in space, according to new research from the Universities of Surrey and Swansea.

The first study of its kind followed a satellite over six years, observing how the panels generated power and weathered solar radiation over 30,000 orbits.

The findings could pave the way for commercially viable solar farms in space.

Professor Craig Underwood, Emeritus Professor of Spacecraft Engineering at the Surrey Space Centre at the University of Surrey, said:

“We are very pleased that a mission designed to last one year is still working after six...

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