Scientists Identify Genes linked to High Production of Key Antibody

A rendering of a nanovial, a microscopic bowl-shaped container that the scientists used to capture individual cells and their secretions. The dark, donut-shaped object to the right is a cell; the blue-and-yellow objects to the left are secreted immunoglobulin G antibodies. (Image courtesy: Rene Chang/University of Washington)

A collaboration led by UCLA and the Seattle Children’s Research Institute has yielded new knowledge about the genes responsible for the production and release of immunoglobulin G, the most common type of antibody in the human body.

The finding has the potential to advance manufacturing of antibody-based therapies for diseases such as cancer and arthritis, as well as the development of medical treatments that rely on the production of antibodies.

Antibodies a...

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A ‘Jupiter’ Hotter than the Sun

An aerial view of the European Southern Observatory’s Very Large Telescope in Paranal, Chile (Photo: J. L. Dauvergne & G. Hüdepohl, atacamaphoto.com/ESO)

The search for exoplanets—planets that orbit stars located beyond the borders of our solar system—is a hot topic in astrophysics. Of the various types of exoplanets, one is hot in the literal sense: hot Jupiters, a class of exoplanets that are physically similar to the gas giant planet Jupiter from our own neighborhood.

Unlike “our” Jupiter, hot Jupiters orbit very close to their stars, complete a full orbit in just a few days or even hours, and—as their name suggests—have extremely high surface temperatures. They hold great fascination for the astrophysics community...

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Dopamine control: Turning off One Ion Channel made Mice Smarter. Turning Off another made them more Motivated.

A graphic illustration of two ion channels in the brain that control dopamine release.

A mosaic expression of two ion channels in dopamine neurons of a mouse’s brain. Researchers have found a way to control dopamine release. Larry Zweifel

Researchers have identified two ion channel switches that regulate the release of dopamine in the brain, a first step that might one day lead to therapeutics for a wide range of diseases and disorders that currently have few solutions.

The switches help regulate learning and motivational state in mice. Humans also have hundreds of these channels, which govern many chemical and hormonal processes that influence behavior and mood. The University of Washington School of Medicine research team hopes to identify drugs to target these channels. Those drug candidates could then be tested in clinical trials.

“The ability to precisely mani...

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Arrays of Quantum Rods could Enhance TVs or Virtual Reality devices

A blue squiggle-like DNA graphic points down in the center emitting light downwards. Two red DNA graphics are pointed up beside it. A structured array composed of triangular rods lie flat on dark gray surface, while the top rows of the arrays contain pieces resembling red pills.

MIT engineers developed a new way to create these arrays, by scaffolding quantum rods onto patterned DNA. Using scaffolds of folded DNA, engineers assembled arrays of quantum rods with desirable photonic properties that could enable them to be used as highly efficient micro-LEDs for televisions or virtual reality devices.

Flat screen TVs that incorporate quantum dots are now commercially available, but it has been more difficult to create arrays of their elongated cousins, quantum rods, for commercial devices. Quantum rods can control both the polarization and color of light, to generate 3D images for virtual reality devices.

Using scaffolds made of folded DNA, MIT engineers have come up with a new way to precisely assemble arrays of quantum rods...

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