New Study Unveils Epigenetic ‘Traffic Lights’ Controlling Stop and Go for Gene Activity

Extended Data Fig. 11
H3K4me3 facilitates the recruitment of factors regulating the release of paused RNAPII at the +1 nucleosome. The H3K4me3 at promoter regions is highly dynamic, and it is maintained by an equilibrium between SET1/COMPASS complexes and KDM5 demethylases at highly transcribed genes. The rapid turnover of H3K4me3 ensures that the pausing step is a highly regulated process by Integrator Complex Subunit 11 (INTS11), where an increase in H3K4me3 leads to a decrease in RNAPII pausing and acute depletion leads to an increase RNAPII pausing.

A major new study in the journal Nature reveals a ‘traffic light’ mechanism controlling genetic activity within cells – a system which could potentially be targeted by cancer drugs already in development...

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Quantum Chemistry: Molecules Caught Tunneling

Blue and red balls fly through a cage and hit a wall

Physicists led by Roland Wester of the University of Innsbruck have now for the first time observed a quantum mechanical tunneling reaction in experiments. The observation can also be described exactly in theory. With the study published in Nature, the scientists provide an important reference for this fundamental effect in chemistry. It is the slowest reaction with charged particles ever observed.

Tunneling reactions in chemistry are very difficult to predict. The quantum mechanically exact description of chemical reactions with more than three particles is difficult, with more than four particles it is almost impossible. Theorists simulate these reactions with classical physics and must neglect quantum effects...

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AI Draws Most Accurate Map of Star Birthplaces in the Galaxy

Osaka Metropolitan University scientists identified about 140,000 molecular clouds in the Milky Way Galaxy from large-scale data of carbon monoxide molecules, observed in detail by the Nobeyama 45-m radio telescope. Using AI, the researchers estimated the distance of each of these molecular clouds to determine their size and mass, successfully mapping the distribution of the molecular clouds in the Galaxy in the most detailed manner to date.

Stars are formed by molecular gas and dust coalescing in space. These molecular gases are so dilute and cold that they are invisible to the human eye, but they do emit faint radio waves that can be observed by radio telescopes.

Observing from Earth, a lot of matter lies ahead and behind these molecular clouds and these overlapping features m...

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New Hydrogel Stem Cell Treatment Repairs Injured Brain Tissue in Mice

Mouse brain tissue
Mouse brain tissue 28 days after injection of hydrogel with myoglobin shows a higher volume of healthy grafted brain tissue, compared to injections of the hydrogel without myoglobin. Image: Supplied.

A new ‘hybrid’ hydrogel, which allows clinicians to safely deliver stem cells to the site of a brain injury in mice, has been developed by researchers from the University of Melbourne and the Australian National University.

A hydrogel is a water-based gel that can be used to deliver substances into the body and can be used to promote the effective growth of new cells.

Published in Nature Communications, the proof-of-concept breakthrough solves a major challenge faced by stem cell researchers since the 1980s – keeping stem cells alive for long enough to allow them to evolve into the c...

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