New Hope for Vision Regeneration by Reactivating Dormant Cells in the Retina

New hope for vision regeneration by reactivating dormant cells in the retina
Ikzf1/4 expression induces morphological reprogramming of MG ex vivo. Credit: Proceedings of the National Academy of Sciences (2023). DOI: 10.1073/pnas.2122168120

There’s new hope for potentially restoring vision in patients suffering from degenerative retinal disease, thanks to work by researchers at Université de Montréal.

Published this week in Proceedings of the National Academy of Sciences, the research was led by UdeM medical professor Michel Cayouette, director of cellular neurobiology research at the UdeM-affiliated Montreal Clinical Research Institute.

His research team discovered that cells that lie dormant in the retina (glial cells) can be induced to tansform into cells sharing some properties with cone photoreceptors, which allow people to do things like perceive c...

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Gas observed Moving into a Massive Galaxy offers Evidence of Material Recycling

Gas observed moving into a massive galaxy offers evidence of material recycling
Direct imaging on the gas recycling around massive galaxy 11 billion years ago. Credit: Department of Astronomy, Tsinghua University

An international team of space scientists has found that observation of a gas cloud stream heading into a massive galaxy may offer evidence of gas material recycling. In their paper published in the journal Science, the group describes their observance and analysis of a gas cloud surrounding a dense galaxy cluster 11 billion light years away, and what they learned from their work.

Space scientists have, for many years, predicted that enriched gases surrounding galaxies could be pulled into such galaxies and wind up as material for making new stars...

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‘Black Sheep’ of Helper T cells may hold key to Precision Allergy Treatment

A new Nature Immunologystudy led by University of Pittsburgh and National Institutes of Health researchers sheds light on how a rare type of helper T cell, called Th9, can drive allergic disease, suggesting new precision medicine approaches to treating allergies in patients with high levels of Th9.

“Th9 cells are kind of like the black sheep of helper T cells,” said senior author Daniella Schwartz, M.D., assistant professor of rheumatology at Pitt’s School of Medicine. “They need a perfect storm of occurrences to pop up, and they aren’t long-lived, which makes them hard to study. The other weird thing about Th9 cells is that they remain functional without seeing their antigen.”

T cells switch on when they encounter viruses, bacteria or other pathogens, causing them to ramp up pr...

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Exciton Fission: One Photon in, two Electrons out

Emergence of the bitriplet exciton in crystalline pentacene.
Emergence of the bitriplet exciton in crystalline pentacene.
© TU Berlin

Photovoltaics, the conversion of light to electricity, is a key technology for sustainable energy. Since the days of Max Planck and Albert Einstein, we know that light as well as electricity are quantized, meaning they come in tiny packets called photons and electrons. In a solar cell, the energy of a single photon is transferred to a single electron of the material, but no more than one. Only a few molecular materials like pentacene are an exception, where one photon is converted to two electrons instead.

“When pentacene is excited by light, the electrons in the material rapidly react,” explains Prof. Ralph Ernstorfer, a senior author of the study...

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