Cancers in Distant Organs Alter Liver Function

Tumor cell-derived EVPs induced accumulation of lipid droplets in the mouse liver. Green, lipid droplet. Blue, DAPI. Credit: Gang Wang, Jianlong Li, David Lyden.
Tumor cell-derived EVPs induced accumulation of lipid droplets in the mouse liver. Green, lipid droplet. Blue, DAPI. Credit: Gang Wang, Jianlong Li, David Lyden.

Cancers often release molecules into the bloodstream that pathologically alter the liver, shifting it to an inflammatory state, causing fat buildup and impairing its normal detoxifying functions, according to a study from investigators at Weill Cornell Medicine. This discovery illuminates one of cancer’s more insidious survival mechanisms and suggests the possibility of new tests and drugs for detecting and reversing this process.

In the study, published May 24 in Nature, the researchers found that a wide variety of tumor types growing outside the liver remotely reprogram the liver to a state resembling fatty liver disease ...

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Protein-based Nano-‘computer’ evolves in ability to Influence Cell Behavior

Jiaxing Chen uses fluorescence microscopy to visualize fixed cells on nanopatterns.
Jiaxing Chen uses fluorescence microscopy to visualize fixed cells on nanopatterns.  Credit: Penn State Huck Institutes of the Life Sciences / Penn State

The first protein-based nano-computing agent that functions as a circuit has been created by Penn State researchers. The milestone puts them one step closer to developing next-generation cell-based therapies to treat diseases like diabetes and cancer.

Traditional synthetic biology approaches for cell-based therapies, such as ones that destroy cancer cells or encourage tissue regeneration after injury, rely on the expression or suppression of proteins that produce a desired action within a cell. This approach can take time (for proteins to be expressed and degrade) and cost cellular energy in the process...

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New study provides Novel Insights into the Cosmic Evolution of Amino Acids

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Image by Triff/Shutterstock

Scientists perform computational simulations for biological molecules detected in meteorites to clarify the origin of life on Earth. All biological amino acids on Earth appear exclusively in their left-handed form, but the reason underlying this observation is elusive. Recently, scientists from Japan uncovered new clues about the cosmic origin of this asymmetry. Based on the optical properties of amino acids found on the Murchison meteorite, they conducted physics-based simulations, revealing that the precursors to the biological amino acids may have determined the amino acid chirality during the early phase of galactic evolution.

If you look at your hands, you will notice that they are mirror images of each other...

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Engineers Harvest Abundant Clean Energy from Thin Air, 24/7

The secret to making electricity from thin air? Nanopores. Credit: Derek Lovley/Ella Maru Studio

A team of engineers at the University of Massachusetts Amherst has recently shown that nearly any material can be turned into a device that continuously harvests electricity from humidity in the air. The secret lies in being able to pepper the material with nanopores less than 100 nanometers in diameter. The research appeared in the journal Advanced Materials.

“This is very exciting,” says Xiaomeng Liu, a graduate student in electrical and computer engineering in UMass Amherst’s College of Engineering and the paper’s lead author. “We are opening up a wide door for harvesting clean electricity from thin air.”

“The air contains an enormous amount of electricity,” says Jun Yao, assistant...

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