Iron induces Chronic Heart Failure in Half of Heart Attack Survivors

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An overarching model of how hemorrhagic infarction promotes chronic heart failure via fat deposition.

A multi-institution study led by Rohan Dharmakumar, PhD, of Indiana University School of Medicine, has identified that iron drives the formation of fatty tissue in the heart and leads to chronic heart failure in about fifty percent of heart attack survivors. The discovery, recently published in Nature Communications, paves the way for treatments that have the potential to prevent heart failure in nearly half a million people a year in the United States, and many millions more worldwide.

“For the first time, we have identified a root cause of chronic heart failure following a heart attack,” Dharmakumar said.

Dharmakumar is executive director of IU’s Krannert Cardiovascular Researc...

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Quantum Dots form Ordered Material

Electron microscope images showing two of the ordered structures formed in the experiments. Atoms inside the quantum dots are resolved by the microscope and it can be seen that they are aligned throughout adjacent dots. A model of the device used for the measurement of the electronic properties is shown in the bottom right. The superlattice lies between two electrodes while an ionic gel on top (gate electrode) is used to accumulate carriers in the active material.
Electron microscope images showing two of the ordered structures formed in the experiments. Atoms inside the quantum dots are resolved by the microscope and it can be seen that they are aligned throughout adjacent dots. A model of the device used for the measurement of the electronic properties is shown in the bottom right. The superlattice lies between two electrodes while an ionic gel on top (gate electrode) is used to accumulate carriers in the active material. | Illustration Jacopo Pinna

Finding paves the way for new generation of opto-electronic applications. Quantum dots are clusters of some 1,000 atoms which act as one large ‘super-atom’. It is possible to accurately design the electronic properties of these dots just by changing their size...

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‘Stripped, Pulsating Core of a Massive Star’ Spotted for the First Time

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Credit: Pixabay/CC0 Public Domain

A trio of researchers from Friedrich-Alexander University Erlangen-Nuremberg, Universität Innsbruck and the University of Geneva, respectively, has discovered a “stripped, pulsating core of a massive star” for the first time. In their paper published in the journal Nature Astronomy, Andreas Irrgang, Norbert Przybilla and Georges Meynet, describe the unique object and the work that they did in verifying its makeup.

Stellar cores, as their name suggests, are the innermost parts of stars. Most often, such cores are covered by what space scientists call their “opaque envelope.” Theory has suggested that such cores can appear without their envelope if conditions arise that lead to its removal. But until now, this had never been observed.

In their pap...

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Scientists discover Anti-Inflammatory molecules that Decline in the Aging Brain

The brain is comprised of lipids or fats, but the role of these molecules in health and disease remains unknown. The newly identified class of lipids, called SGDGs, decrease with aging, which suggests they may play a role in brain aging.
Credit: Salk Institute

The molecules, called SGDGs, may lead to new ways to treat age-related neurological diseases. Aging involves complicated plot twists and a large cast of characters: inflammation, stress, metabolism changes, and many others. Now, a team of Salk Institute and UC San Diego scientists reveal another factor implicated in the aging process — a class of lipids called SGDGs (3-sulfogalactosyl diacylglycerols) that decline in the brain with age and may have anti-inflammatory effects.

The research, published in Nature Chemical Biology on...

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