Widespread Tumor Suppression Mechanism Stops Cancer Progression by interfering with cancer cell Metabolism

Novel Parkin ubiquitome in cancer.(A) Bioinformatics analysis of predicted protein networks regulated by Parkin ubiquitination in the absence of mitochondrial uncoupling, including cell death (HK1, MCL1, and HMGB1), glucose metabolism involving glycolysis (HK1 and TPI1) and the PPP (TALDO1 and TKT), protein folding (CCT7 and HSPA1A, also known as HSP72), and mitochondrial dynamics (RHOT1, FIS1, and MFN2). Parkin-directed ubiquitination sites (Lys, K) identified by SILAC proteomics in each target protein are indicated. (B) PC3 cells in the presence or absence of Parkin were immunoprecipitated with an antibody to MFN2, and immune complexes were probed with antibodies to ubiquitin (Ub) or MFN2 by Western blotting. IP, immunoprecipitation; IB, immunoblot. (C) The conditions are as in (B) exce...
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Like venom coursing through the body: Researchers identify Mechanism driving COVID-19 Mortality

Students in white lab coats and safety gear stand around a microscope in Dr. Chilton's lab
In a photo taken prior to the pandemic, Dr. Chilton (second from left) and his lab team examine how genetic and epigenetic variations interact with human diets to drive inflammation and inflammatory disorders, as well as psychiatric and developmental disorders.Chris Richards/University of Arizona

An enzyme with an elusive role in severe inflammation may be a key mechanism driving COVID-19 severity and could provide a new therapeutic target to reduce COVID-19 mortality, according to a study published in the Journal of Clinical Investigation.

Researchers from the University of Arizona, in collaboration with Stony Brook University and Wake Forest University School of Medicine, analyzed blood samples from two COVID-19 patient cohorts and found that circulation of the enzyme – secreted p...

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Quantum Computing: Exotic Particle had an ‘Out-of-Body Experience’

Artist’s illustration of ghost particles moving through a quantum spin liquid. (Credit: Jenny Nuss/Berkeley Lab)

An unexpected finding could advance quantum computers and high-temperature superconductors. Scientists have taken the clearest picture yet of electronic particles that make up a mysterious magnetic state called quantum spin liquid (QSL).

The achievement could facilitate the development of superfast quantum computers and energy-efficient superconductors.

The scientists are the first to capture an image of how electrons in a QSL decompose into spin-like particles called spinons and charge-like particles called chargons.

“Other studies have seen various footprints of this phenomenon, but we have an actual picture of the state in which the spinon lives...

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Unveiling a Century-old Mystery: Where the Milky Way’s Cosmic Rays come from

Astronomers have succeeded for the first time in quantifying the proton and electron components of cosmic rays in a supernova remnant. At least 70% of the very-high-energy gamma rays emitted from cosmic rays are due to relativistic protons, according to the novel imaging analysis of radio, X-ray, and gamma-ray radiation. The acceleration site of protons, the main components of cosmic rays, has been a 100-year mystery in modern astrophysics, this is the first time that the amount of cosmic rays being produced in a supernova remnant has been quantitatively shown and is an epoch-making step in the elucidation of the origin of cosmic rays.

The origin of cosmic rays, the particles with the highest energy in the universe, has been a great mystery since their discovery in 1912...

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