Gene Therapy boosts Parkinson’s Disease Drug Benefits

A new gene therapy targeting the small brain region where dopamine neurons reside, the substantia nigra, substantially boosts the benefits of the drug levodopa in Parkinson’s. The therapy restored the ability of these neurons to convert levodopa to dopamine. Scientists also showed how damage to the powerplants inside dopamine-releasing neurons triggers Parkinson’s. The findings may help identify humans in the earliest stages of Parkinson’s disease, develop therapies to slow disease progression and treat late-stage disease.

In late-stage Parkinson’s disease, the drug levodopa becomes less effective in treating symptoms because of the inexorable loss of dopamine-releasing neurons...

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Making Aircraft Fuel from Sunlight and Air

Research plant in Zurich: The chemical process is powered by solar energy.
Research plant in Zurich: The chemical process is powered by solar energy. ETH Zürich / Alessandro Della Bella

Scientists at ETH Zurich have built a plant that can produce carbon-neutral liquid fuels from sunlight and air. The next goal will be to take this technology to industrial scale and achieve competitiveness. In a paper published in the journal Nature, researchers from Zurich and Potsdam describe how this novel solar reactor functions and outline a policy framework that would provide incentives to expand the production of “solar kerosene.”

Carbon-neutral fuels are crucial for making aviation and maritime transport sustainable...

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Gravitational ‘Kick’ may explain the Strange Shape at the Center of Andromeda

Click to enlarge: Graphic showing the orbit of stars around a supermassive black hole before, left, and after, right, a gravitational “kick.” (Credit: Steven Burrows/JILA)

When two galaxies collide, the supermassive black holes at their cores release a devastating gravitational “kick,” similar to the recoil from a shotgun. New research led by CU Boulder suggests that this kick may be so powerful it can knock millions of stars into wonky orbits.

The research, published Oct. 29 in The Astrophysical Journal Letters, helps solve a decades-old mystery surrounding a strangely-shaped cluster of stars at the heart of the Andromeda Galaxy. It might also help researchers better understand the process of how galaxies grow by feeding on each other.

“When scientists first looked at Andromeda,...

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Combining two ‘Old Therapies’ packs a Powerful Punch against Pediatric Brain Tumors

On the left is a magnetic resonance image of a child’s medulloblastoma brain tumor, and on the right, a photomicrograph of medulloblastoma cells. The circle shows a Homer Wright rosette, a circular cluster of tumor cells characteristic of the disease. Johns Hopkins Medicine researchers have combined two old therapies — copper and disulfiram — to destroy this pediatric cancer. Credit: Graphic created by M.E. Newman, Johns Hopkins Medicine, using public domain images. MRI scan courtesy of the National Cancer Institute and photomicrograph courtesy of Jensflorian via Wikimedia Commons.

Copper has been clinically improving the lives of people since about 1500 BCE, when an Egyptian physician first recorded its use as a treatment for inflammation...

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