activated neural stem cells appear to favor proteasomes over lysosomes tagged posts

Resting neural stem cells (nuclei shown in blue) accumulate large protein aggregates (pink) in and around storage compartments called lysosomes (green). Credit: Xiaoai Zhao

Young, resting neural stem cells in the brains of mice store large clumps of proteins in specialized cellular trash compartments known as lysosomes, researchers at the Stanford University School of Medicine have found. As the cells age, they become less proficient at disposing of these protein aggregates, and their ability to respond readily to “make new neurons” signals wanes. Restoring the ability of the lysosomes to function normally rejuvenates the cells’ ability to activate.

The discovery of the aggregates in young stem cells was unexpected, in part because similar aggregates are associated with the development of ...