cognitive decline tagged posts

The gut can drive age-associated memory loss, research reveals

The gut can drive age-associated memory loss
An intestinal immune cell detects medium-chain fatty acids produced by aging gut bacteria through the GPR84 receptor, releasing inflammatory molecules that block signaling along the vagus nerve to the hippocampus. Disruption of this gut-brain pathway drives age-associated cognitive decline. Credit: Thaiss Lab

We become forgetful as we age. This is often seen as a universal truth, but in fact it is far from universal: some people remain incredibly sharp at 100 years old, while others experience memory loss starting in middle age.

While it seems logical that age-related cognitive decline would be blamed on brain aging and degeneration (which, like anything in the brain, is notoriously hard to treat), there’s some evidence that processes elsewhere in the body influence the brain’s abil...

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Type 2 Diabetes Accelerates Brain Aging and Cognitive Decline

Aging effects on the brain, further exacerbated in type 2 diabetes. Image credit: Lilianne Mujica-Parodi (CC BY 4.0)

Scientists have demonstrated that normal brain aging is accelerated by approximately 26% in people with progressive type 2 diabetes compared with individuals without the disease, reports a study published today in eLife.

The authors evaluated the relationship between typical brain aging and that seen in type 2 diabetes, and observed that type 2 diabetes follows a similar pattern of neurodegeneration as aging, but which progresses faster. One important implication of this finding is that even typical brain aging may reflect changes in the brain’s regulation of glucose by insulin.

The results further suggest that by the time type 2 diabetes is formally diagnosed, the...

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AI-enabled ECGs may Identify Patients at Greater risk of Stroke, Cognitive Decline

Atrial fibrillation, the most common cardiac rhythm abnormality, has been linked to one-third of ischemic strokes, the most common type of stroke. But atrial fibrillation is underdiagnosed, partly because many patients are asymptomatic.

Artificial intelligence-enabled electrocardiography (ECG) was recently shown to identify the presence of brief episodes of atrial fibrillation, and the ability of an AI-enabled ECG algorithm to predict atrial fibrillation up to 10 years before clinical diagnosis has been confirmed in a population-based study conducted by Mayo Clinic researchers.

A new population-based study from Mayo Clinic now offers evidence that the algorithm can help identify patients at greater risk of cognitive decline...

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Hit the Sleep ‘Sweet Spot’ to keep Brain Sharp

Older adults who sleep short or long experienced greater cognitive decline than those who sleep a moderate amount, even when the effects of early Alzheimer’s disease were taken into account, according to a study by researchers at Washington University School of Medicine in St. Louis. Getty Images

Too little and too much sleep linked to cognitive decline. Like so many other good things in life, sleep is best in moderation. A multiyear study of older adults found that both short and long sleepers experienced greater cognitive decline than people who slept a moderate amount, even when the effects of early Alzheimer’s disease were taken into account. The study was led by researchers at Washington University School of Medicine in St. Louis.

Poor sleep and Alzheimer’s disease are both a...

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